Increased Risk of Clinically Significant Gallstones following an Appendectomy: A Five-Year Follow-Up Study

Although the vermiform appendix is commonly considered a vestigial organ, adverse health consequences after an appendectomy have garnered increasing attention. In this study, we investigated the risks of gallstone occurrence during a 5-year follow-up period after an appendectomy, using a population-...

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Bibliographic Details
Published in:PloS one 2016-10, Vol.11 (10), p.e0165829-e0165829
Main Authors: Chung, Shiu-Dong, Huang, Chung-Chien, Lin, Herng-Ching, Tsai, Ming-Chieh, Chen, Chao-Hung
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Adult
Aged
Appendectomy
Appendectomy - adverse effects
Appendicitis
Appendix
Biology and Life Sciences
Cancer
Cholecystectomy
Clinical significance
Diabetes
Diagnosis
Female
Follow-Up Studies
Gallbladder diseases
Gallstones
Gallstones - epidemiology
Gastroenterology
Health hazards
Health insurance
Hepatology
Hospitals
Humans
Informatics
Male
Medical diagnosis
Medicine and Health Sciences
Middle Aged
Patients
Population
Regression analysis
Risk
Risk Factors
Studies
Surgery
Thoracic surgery
Young Adult
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Summary:Although the vermiform appendix is commonly considered a vestigial organ, adverse health consequences after an appendectomy have garnered increasing attention. In this study, we investigated the risks of gallstone occurrence during a 5-year follow-up period after an appendectomy, using a population-based dataset. We used data from the Taiwan Longitudinal Health Insurance Database 2005. The exposed cohort included 4916 patients who underwent an appendectomy. The unexposed cohort was retrieved by randomly selecting 4916 patients matched with the exposed cohort in terms of sex, age, and year. We individually tracked each patient for a 5-year period to identify those who received a diagnosis of gallstones during the follow-up period. Cox proportional hazard regressions were performed for the analysis. During the 5-year follow-up period, the incidence rate per 1000 person-years was 4.71 for patients who had undergone an appendectomy, compared to a rate of 2.59 for patients in the unexposed cohort (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0165829