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Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring

Recent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of...

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Published in:PloS one 2016-11, Vol.11 (11), p.e0165432
Main Authors: Ramírez-López, María Teresa, Arco, Raquel, Decara, Juan, Vázquez, Mariam, Noemí Blanco, Rosario, Alén, Francisco, Suárez, Juan, Gómez de Heras, Raquel, Rodríguez de Fonseca, Fernando
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cited_by cdi_FETCH-LOGICAL-c725t-e4a6a322517ea05adfc7b58fc63ce936dfcf03b064c28ccee2377539f9263ca63
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creator Ramírez-López, María Teresa
Arco, Raquel
Decara, Juan
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Noemí Blanco, Rosario
Alén, Francisco
Suárez, Juan
Gómez de Heras, Raquel
Rodríguez de Fonseca, Fernando
description Recent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of endocannabinoid-related behaviors, b) the metabolic profile of adult offspring and c) the mRNA expression of the signaling machinery of the ECS in the hypothalamus, the liver and the adipose tissue of adult offspring of both sexes. Exposure to a palatable diet resulted in a) sex-dimorphic and perinatal diet specific feeding behaviors, including the differential response to the inhibitory effects of the cannabinoid receptor inverse agonist AM251, b) features of metabolic syndrome including increased adiposity, hyperleptinemia, hypertriglyceridemia and hypercholesterolemia and c) tissue and sex-specific changes in the expression of both CB1 and CB2 receptors and in that of the endocannabinoid-degrading enzymes FAAH and MAGL, being the adipose tissue the most affected organ analyzed. Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.
doi_str_mv 10.1371/journal.pone.0165432
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Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27806128</pmid><doi>10.1371/journal.pone.0165432</doi><tpages>e0165432</tpages><orcidid>https://orcid.org/0000-0002-4516-5795</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2016-11, Vol.11 (11), p.e0165432
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1835681834
source NCBI_PubMed Central(免费); ProQuest - Publicly Available Content Database
subjects Adipose tissue
Adipose Tissue - metabolism
Animals
Animals, Newborn
Biology and Life Sciences
Body fat
Brain
Brain - metabolism
Cannabinoid CB2 receptors
Diet
Diet, High-Fat - adverse effects
DNA methylation
Endocannabinoid system
Endocannabinoids - metabolism
Energy expenditure
Enzymes
Epidemics
Exposure
Fatty-acid amide hydrolase
Feeding behavior
Female
Food
Gene expression
Gene Expression Regulation, Developmental - drug effects
Gestation
Homeostasis
Hospitals
Hypercholesterolemia
Hypertriglyceridemia
Hypothalamus
Impact analysis
Insulin resistance
Lactation
Liver
Liver - metabolism
Long-term effects
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Obesity
Offspring
Perinatal exposure
Piperidines - pharmacology
Pregnancy
Pyrazoles - pharmacology
Rats
Receptor, Cannabinoid, CB1 - metabolism
Receptor, Cannabinoid, CB2 - metabolism
Receptors
Rodents
Sex
Sex Characteristics
Signal Transduction - drug effects
Signaling
Weaning
title Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring
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