Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study

• Published in: PloS one 2016-10, Vol.11 (10), p.e0165325-e0165325
• Main Authors: Kim, Ho Sun, Shin, Joon-Shik, Lee, Jinho, Lee, Yoon Jae, Kim, Me-Riong, Bae, Young-Hyeon, Park, Ki Byung, Lee, Eun-Jung, Kim, Joo-Hee, Ha, In-Hyuk
• Format: Article
• Language: English
• Subjects: Adult; Aged; Arthritis; Atherosclerosis; Back pain; Biocompatibility; Biology and Life Sciences; Blood Glucose - analysis; Blood pressure; Blood Pressure - physiology; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - etiology; Cholesterol; Cholesterol - blood; Comorbidity; Confidence intervals; Continuity (mathematics); Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Disease control; Female; Health care costs; Health care policy; Health risk assessment; Health risks; Hostages; Humans; Hypertension; Hypertension - complications; Knee; Knee - diagnostic imaging; Koreans; Male; Medical research; Medicine and Health Sciences; Metabolism; Middle Aged; Mortality; Nutrition; Nutrition Surveys; Osteoarthritis; Osteoarthritis, Knee - diagnosis; Osteoarthritis, Knee - etiology; Pain; Pain - pathology; Pathology; People and Places; Personal health; Population; Prevalence; Prevention; Public health; Republic of Korea; Risk analysis; Risk Factors; Smoking; Special interest groups; Stock price indexes; Surveys; Type 2 diabetes; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0165325

Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors. A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis. Knee osteoarthritis patients were defined as participants with K-L grade ≥2 on knee X-ray regardless of knee pain. The association between major cardiovascular risk factors (blood pressure, diabetes, cholesterol, and smoking habits), FRS, and knee osteoarthritis was analyzed, adjusting for various covariates. Prevalence of knee osteoarthritis in Koreans aged ≥50 years was 36.6%, and higher in women (men: 24.9%, women: 45.4%). Prevalence of knee osteoarthritis in participants with hypertension was significantly higher than those without hypertension (fully adjusted odds ratio (OR) 1.26; 95% confidence interval (CI) 1.08-1.48). Knee osteoarthritis prevalence was also higher in participants with impaired fasting glucose or diabetes than those without (age, sex adjusted OR 1.19; 95% CI 1.00-1.41). Also, OR values increased statistically significantly with FRS as a continuous variable (fully adjusted OR 1.007; 95% CI 1.00-1.01). Prevalence of knee osteoarthritis was associated with hypertension and diabetes, which are major cardiovascular risk factors, and the FRS. Further studies on FRS pertaining to its relationship with osteoarthritis are warranted.