Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity

• Published in: PloS one 2016-11, Vol.11 (11), p.e0166712
• Main Authors: Chang, Ming-Ling, Kuo, Chia-Jung, Huang, Hsin-Chih, Chu, Yin-Yi, Chiu, Cheng-Tang
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alanine; Alanine transaminase; Alanine Transaminase - metabolism; Alcohol; Analysis; Anthropometry; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological response modifiers; Biology and Life Sciences; Biopsy; Body mass; Body Mass Index; Body size; Cardiovascular disease; Care and treatment; Cholesterol; Complement; Complement C3 - metabolism; Complement C4 - metabolism; Complement component C3; Complement component C4; Complement System Proteins - metabolism; Diabetes; Fasting; Fatty acids; Fatty liver; Female; Gastroenterology; Gene expression; Genotype; Genotype & phenotype; Genotypes; Health aspects; Hepacivirus - drug effects; Hepacivirus - genetics; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - genetics; Hepatitis C, Chronic - metabolism; Hepatology; Homeostasis; Hospitals; Humans; Immune clearance; Immunity; Infection; Infections; Insulin resistance; Interferon; Interferons; Interleukins - genetics; Leptin; Leptin - metabolism; Leukocytes; Liver; Liver cancer; Liver diseases; Male; Medical research; Medicine and health sciences; Metabolism; Middle Aged; Patients; Physical Sciences; Physiological aspects; Polymorphism, Single Nucleotide; Prospective Studies; Proteins; Research and Analysis Methods; Ribonucleic acid; RNA; RNA, Viral - genetics; Rodents; Steatosis; Sustained Virologic Response; Therapy; Viruses; White blood cell count
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0166712

The association between leptin and complement in hepatitis C virus (HCV) infection remains unknown. A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels. Of the 474 patients, 395 had a sustained virological response (SVR). Pre-therapy leptin levels did not differ between patients with and without an SVR. Univariate and multivariate analyses showed that sex (pre- and post-therapy, p