Extensive Association of Common Disease Variants with Regulatory Sequence

Overlap between non-coding DNA regulatory sequences and common variant associations can help to identify specific cell and tissue types that are relevant for particular diseases. In a systematic manner, we analyzed variants from 94 genome-wide association studies (reporting at least 12 loci at p

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Bibliographic Details
Published in:PloS one 2016-11, Vol.11 (11), p.e0165893-e0165893
Main Authors: Mokry, Michal, Harakalova, Magdalena, Asselbergs, Folkert W, de Bakker, Paul I W, Nieuwenhuis, Edward E S
Format: Article
Language:English
Subjects:
Adrenal glands
Adult
Alzheimer Disease - genetics
Alzheimer's disease
Alzheimers disease
Analysis
Bioinformatics
Biology and Life Sciences
Bone density
Bone marrow
Cardiology
Cell lines
Consortia
Coronary artery
Coronary artery disease
Coronary Artery Disease - genetics
Databases, Nucleic Acid
Datasets
Deoxyribonuclease
Deoxyribonucleic acid
Diseases
DNA
Epigenetics
Female
Fetuses
Gene expression
Gene sequencing
Genetic aspects
Genome-wide association studies
Genome-Wide Association Study
Genomes
Health sciences
Heart diseases
Humans
Immune system
Immune System Diseases - genetics
Immunology
Inflammatory bowel diseases
Inflammatory Bowel Diseases - genetics
Intestine
Kidney diseases
Male
Medicine and Health Sciences
Menarche
Myopia
Noncoding DNA
Nucleotide sequence
Organs
Pediatrics
Physiological regulation
Regulatory mechanisms (biology)
Regulatory sequences
Regulatory Sequences, Nucleic Acid
Tissues
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Description
Summary:Overlap between non-coding DNA regulatory sequences and common variant associations can help to identify specific cell and tissue types that are relevant for particular diseases. In a systematic manner, we analyzed variants from 94 genome-wide association studies (reporting at least 12 loci at p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0165893