Degenerative Suspensory Ligament Desmitis (DSLD) in Peruvian Paso Horses Is Characterized by Altered Expression of TGFβ Signaling Components in Adipose-Derived Stromal Fibroblasts

Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that...

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Bibliographic Details
Published in:PloS one 2016-11, Vol.11 (11), p.e0167069-e0167069
Main Authors: Luo, Wei, Sandy, John, Trella, Katie, Gorski, Daniel, Gao, Shuguang, Li, Jun, Brounts, Sabrina, Galante, Jorge, Plaas, Anna
Format: Article
Language:English
Subjects:
Activating transcription factor 3
Adipose Tissue - pathology
Animal husbandry
Animals
Biochemistry
Biology and life sciences
Bone surgery
Breeding
Chondroitin sulfate
Chromatin - metabolism
Collagen
Fibrils
Fibroblasts
Fibroblasts - drug effects
Fibroblasts - pathology
Gene expression
Gene Expression Regulation - drug effects
Genes
Growth factors
Health risks
Horse Diseases - pathology
Horses
Internal medicine
Ligaments
Male
Medicine
Medicine and Health Sciences
Orthopedics
Protein-Serine-Threonine Kinases - antagonists & inhibitors
Pyrazoles - pharmacology
Pyrroles - pharmacology
Receptors, Transforming Growth Factor beta - antagonists & inhibitors
Regulators
Signal Transduction - drug effects
Signaling
Stem cells
Stromal Cells - pathology
Tendons
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta1 - pharmacology
Transforming growth factor-b1
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Summary:Equine degenerative suspensory ligament desmitis (DSLD) in Peruvian Paso horses typically presents at 7-15 years and is characterized by lameness, focal disorganization of collagen fibrils, and chondroid deposition in the body of the ligament. With the aim of developing a test for disease risk (that can be used to screen horses before breeding) we have quantified the expression of 76 TGFβ-signaling target genes in adipose-derived stromal fibroblasts (ADSCs) from six DSLD-affected and five unaffected Paso horses. Remarkably, 35 of the genes showed lower expression (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0167069