Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer

HER-2 positive tumors are among the most aggressive subtypes of breast cancer and are frequently associated with metastasis and poor outcome. As with other aggressive subtypes of breast cancer, these tumors are associated with abnormally high expression of galectin-7 (gal-7), which confers metastati...

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Published in:PloS one 2016-11, Vol.11 (11), p.e0166731-e0166731
Main Authors: Grosset, Andrée-Anne, Poirier, Françoise, Gaboury, Louis, St-Pierre, Yves
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Breast cancer
Cancer
Care and treatment
Cell Line, Tumor
Cell Proliferation - genetics
Cell Transformation, Neoplastic - genetics
Cellular Biology
Change detection
Development and progression
Disease
Disease Models, Animal
Disease Progression
ErbB-2 protein
Female
Galectins - genetics
Gene amplification
Gene expression
Genetic aspects
Genetic engineering
Glands
Health aspects
Humans
Invasiveness
Lectins
Life Sciences
Longevity - genetics
Mammary gland
Mammary glands
Mammary Glands, Animal - metabolism
Mammary Neoplasms, Animal - mortality
Mammary Neoplasms, Animal - pathology
Mammary Tumor Virus, Mouse
MCF-7 Cells
Medicine and Health Sciences
Metastases
Metastasis
Mice
Mice, Inbred C57BL
Mice, Knockout
Phenotypes
Receptor, ErbB-2 - metabolism
Research and Analysis Methods
Rodents
Transgenic animals
Transgenic mice
Tumor cells
Tumorigenesis
Tumors
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creator Grosset, Andrée-Anne
Poirier, Françoise
Gaboury, Louis
St-Pierre, Yves
description HER-2 positive tumors are among the most aggressive subtypes of breast cancer and are frequently associated with metastasis and poor outcome. As with other aggressive subtypes of breast cancer, these tumors are associated with abnormally high expression of galectin-7 (gal-7), which confers metastatic breast tumor cells with increased invasive behavior. Although previous studies in the rat model of breast tumorigenesis have shown that gal-7 is also increased in primary breast tumor, its contribution to the development of the primary breast tumors remains unclear. In the present work, we have used genetically-engineered gal-7-deficient mice to examine the role of gal-7 in the development of the mammary gland and of breast cancer. Using histological and immunohistological analysis of whole mammary glands at different stages of development, we detected no significant changes between normal and gal-7-deficient mice. To test the involvement of gal-7 in breast cancer, we next examined the effects of loss of gal-7 on mammary tumor development by crossing gal-7-deficient mice with the mammary tumor transgenic mouse strain FVB-Tg(MMTV-Erbb2)NK1Mul/J. Finally, assessment of mice survival and tumor volume showed a delay of mammary tumor growth in the absence of systemic gal-7. These data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer.
doi_str_mv 10.1371/journal.pone.0166731
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To test the involvement of gal-7 in breast cancer, we next examined the effects of loss of gal-7 on mammary tumor development by crossing gal-7-deficient mice with the mammary tumor transgenic mouse strain FVB-Tg(MMTV-Erbb2)NK1Mul/J. Finally, assessment of mice survival and tumor volume showed a delay of mammary tumor growth in the absence of systemic gal-7. These data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27902734</pmid><doi>10.1371/journal.pone.0166731</doi><tpages>e0166731</tpages><oa>free_for_read</oa></addata></record>
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source Publicly Available Content Database; PubMed Central
subjects Animals
Biology and Life Sciences
Breast cancer
Cancer
Care and treatment
Cell Line, Tumor
Cell Proliferation - genetics
Cell Transformation, Neoplastic - genetics
Cellular Biology
Change detection
Development and progression
Disease
Disease Models, Animal
Disease Progression
ErbB-2 protein
Female
Galectins - genetics
Gene amplification
Gene expression
Genetic aspects
Genetic engineering
Glands
Health aspects
Humans
Invasiveness
Lectins
Life Sciences
Longevity - genetics
Mammary gland
Mammary glands
Mammary Glands, Animal - metabolism
Mammary Neoplasms, Animal - mortality
Mammary Neoplasms, Animal - pathology
Mammary Tumor Virus, Mouse
MCF-7 Cells
Medicine and Health Sciences
Metastases
Metastasis
Mice
Mice, Inbred C57BL
Mice, Knockout
Phenotypes
Receptor, ErbB-2 - metabolism
Research and Analysis Methods
Rodents
Transgenic animals
Transgenic mice
Tumor cells
Tumorigenesis
Tumors
title Galectin-7 Expression Potentiates HER-2-Positive Phenotype in Breast Cancer
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