DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis

Methylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological g...

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Bibliographic Details
Published in:PloS one 2016-12, Vol.11 (12), p.e0167228-e0167228
Main Authors: Dai, Lihe, Ma, Chong, Zhang, Zhensheng, Zeng, Shuxiong, Liu, Anwei, Tang, Shijie, Ren, Qian, Sun, Yinghao, Xu, Chuanliang
Format: Article
Language:English
Subjects:
Bioindicators
Biological markers
Biology and life sciences
Biomarkers
Biomarkers, Tumor
Bladder
Bladder cancer
Cancer
Case-Control Studies
Data collection
Deactivation
Death-associated protein kinase
Death-Associated Protein Kinases - genetics
Deoxyribonucleic acid
Diagnosis
DNA
DNA Methylation
Epigenetics
Genes
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease
Health aspects
Health risks
Hospitals
Humans
Inactivation
Kinases
Lung cancer
Medical research
Medicine and Health Sciences
Meta-analysis
Methylation
Neoplasm Grading
Neoplasm Staging
Odds Ratio
Physical Sciences
Promoter Regions, Genetic
Protein kinases
Proteins
Publication Bias
Research and Analysis Methods
Risk
Risk factors
Studies
Systematic review
Toxicology
Transcription
Transcription (Genetics)
Tumor suppressor genes
Tumorigenesis
Urinary bladder
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urine
Urology
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Description
Summary:Methylation of tumor suppressor gene promoter leads to transcription inactivation and is involved in tumorigenesis. Several studies demonstrate a potential association between the Death-Associated Protein Kinase (DAPK) gene promoter methylation and bladder cancer risk, tumor stage and histological grade. Due to inconsistent results of these studies, we performed this meta-analysis to ascertain the association. Studies were retrieved from the PubMed, Embase, Web of Science and the Cochrane Library databases. Study selection and data extraction were executed by two reviewers independently. Meta-analysis was performed using Stata 13.0 and Review Manager 5.3 software. A total of 21 articles involving 15 case control and 8 case series studies were included in this meta-analysis. DAPK promoter methylation was associated with bladder cancer risk (OR: 5.81; 95%CI = 3.83-8.82, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0167228