Mupirocin in the Treatment of Staphylococcal Infections in Chronic Rhinosinusitis: A Meta-Analysis

Saline irrigation of the nasal cavity is a classic and effective treatment for acute or chronic rhinosinusitis. Topical antibiotics such as mupirocin have been widely used for recalcitrant chronic rhinosinusitis. Therefore, the purpose of this study was to evaluate the effect of saline irrigation us...

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Bibliographic Details
Published in:PloS one 2016-12, Vol.11 (12), p.e0167369-e0167369
Main Authors: Kim, Jong Seung, Kwon, Sam Hyun
Format: Article
Language:English
Subjects:
Administration, Intranasal
Antibiotics
Bias
Biofilms
Biology and Life Sciences
Biomedical research
Care and treatment
Chronic infection
Clinical medicine
Data processing
Dosage and administration
Health aspects
Health risks
Humans
Irrigation
Literature reviews
Medicine
Medicine and Health Sciences
Meta-analysis
Mupirocin
Mupirocin - therapeutic use
Nasal Cavity - drug effects
Nasal Cavity - microbiology
Nasal Lavage
Nose
Otolaryngology
Paranasal Sinuses - drug effects
Paranasal Sinuses - microbiology
Physical Sciences
Randomized Controlled Trials as Topic
Research and Analysis Methods
Retrospective Studies
Rhinitis
Rhinitis - drug therapy
Rhinitis - microbiology
Rhinosinusitis
Sensitivity analysis
Sinuses
Sinusitis
Sinusitis - drug therapy
Sinusitis - microbiology
Staphylococcal infections
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - pathogenicity
Staphylococcus infections
Studies
Surgery
Surgical outcomes
Systematic review
Therapeutic Irrigation
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Summary:Saline irrigation of the nasal cavity is a classic and effective treatment for acute or chronic rhinosinusitis. Topical antibiotics such as mupirocin have been widely used for recalcitrant chronic rhinosinusitis. Therefore, the purpose of this study was to evaluate the effect of saline irrigation using mupirocin. A systematic literature review and meta-analysis of mupirocin saline irrigation were performed using EMBASE, MEDLINE, and Cochrane library through December 2015. Data were analyzed with R 3.2.2 software. A random effects model was used because of the diversity of included studies. Sensitivity analysis of particular tested groups and single proportion tests were also performed. The main outcome measure was residual staphylococcal infection, as confirmed by culture or PCR. Two RCTs, two prospective studies and two retrospective studies were included. A random effects model meta-analysis of the pooled data identified a relative risk of residual infection of 0.13 (95% CI: 0.06-0.26, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0167369