Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study

The average human life expectancy is increasing worldwide, thus the proportion of elderly gastric cancer patients is also increasing. In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. From January 2004 to December 2010, 2...

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Published in:PloS one 2016-12, Vol.11 (12), p.e0167615-e0167615
Main Authors: Park, Hee Jung, Ahn, Ji Yong, Jung, Hwoon-Yong, Lee, Jeong Hoon, Jung, Kee Wook, Kim, Do Hoon, Choi, Kee Don, Song, Ho June, Lee, Gin Hyug, Kim, Jin-Ho, Han, Seungbong
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Aged, 80 and over
Aging
Cancer
Cancer patients
Cancer therapies
Case studies
Case-Control Studies
Chemotherapy
Classification
Clinical outcomes
Diagnosis
Elderly
Elderly people
Endoscopy
Female
Gastric cancer
Geriatrics
Health aspects
Health care facilities
Health risk assessment
Helicobacter pylori
Humans
Industrialized nations
Life expectancy
Life span
Male
Medical services
Medicine and Health Sciences
Metastasis
Middle Aged
Older people
Patient outcomes
Patients
People and Places
Prognosis
Republic of Korea
Retrospective Studies
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - epidemiology
Stomach Neoplasms - therapy
Surgery
Survival
Survival Rate
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creator Park, Hee Jung
Ahn, Ji Yong
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Choi, Kee Don
Song, Ho June
Lee, Gin Hyug
Kim, Jin-Ho
Han, Seungbong
description The average human life expectancy is increasing worldwide, thus the proportion of elderly gastric cancer patients is also increasing. In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. From January 2004 to December 2010, 291 patients aged over 80 years old (case group) were diagnosed and treated with gastric cancer at Asan Medical Center, Seoul, Korea. From the same period, 291 patients aged 18 to 80 years old were selected as the control group. The clinical findings and clinical outcomes of gastric cancer were retrospectively reviewed and compared between the two groups. There were significant differences in the overall 5-year survival rate between the case and control groups (30.9% vs. 73.8%, respectively; P
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In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. From January 2004 to December 2010, 291 patients aged over 80 years old (case group) were diagnosed and treated with gastric cancer at Asan Medical Center, Seoul, Korea. From the same period, 291 patients aged 18 to 80 years old were selected as the control group. The clinical findings and clinical outcomes of gastric cancer were retrospectively reviewed and compared between the two groups. There were significant differences in the overall 5-year survival rate between the case and control groups (30.9% vs. 73.8%, respectively; P&lt;0.001). In patients who received the curative treatment, overall 3- and 5-year survival rates showed 74.3% and 57.9% in case group and 91.6% and 86.5% in the control group. When analysis was confined to resectable elderly patients with a favorable performance, the curative resection group showed significantly better overall 3- and 5-year survival rates than the conservative treatment group (73.7% and 58.8% vs. 29.8% and 0%, respectively). Although elderly gastric cancer patients show an advanced stage at diagnosis and poor prognosis compared with non-elderly patients, elderly patients with good performance could benefit from curative resection. Thus, the clinical decision whether to undergo curative resection or conservative management should be made on an individualized basis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0167615</identifier><identifier>PMID: 27942044</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Aging ; Cancer ; Cancer patients ; Cancer therapies ; Case studies ; Case-Control Studies ; Chemotherapy ; Classification ; Clinical outcomes ; Diagnosis ; Elderly ; Elderly people ; Endoscopy ; Female ; Gastric cancer ; Geriatrics ; Health aspects ; Health care facilities ; Health risk assessment ; Helicobacter pylori ; Humans ; Industrialized nations ; Life expectancy ; Life span ; Male ; Medical services ; Medicine and Health Sciences ; Metastasis ; Middle Aged ; Older people ; Patient outcomes ; Patients ; People and Places ; Prognosis ; Republic of Korea ; Retrospective Studies ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - epidemiology ; Stomach Neoplasms - therapy ; Surgery ; Survival ; Survival Rate</subject><ispartof>PloS one, 2016-12, Vol.11 (12), p.e0167615-e0167615</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Park et al. 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In this case-control study, we investigated the clinical and oncologic outcomes of gastric cancer in patients over 80 years old. From January 2004 to December 2010, 291 patients aged over 80 years old (case group) were diagnosed and treated with gastric cancer at Asan Medical Center, Seoul, Korea. From the same period, 291 patients aged 18 to 80 years old were selected as the control group. The clinical findings and clinical outcomes of gastric cancer were retrospectively reviewed and compared between the two groups. There were significant differences in the overall 5-year survival rate between the case and control groups (30.9% vs. 73.8%, respectively; P&lt;0.001). In patients who received the curative treatment, overall 3- and 5-year survival rates showed 74.3% and 57.9% in case group and 91.6% and 86.5% in the control group. When analysis was confined to resectable elderly patients with a favorable performance, the curative resection group showed significantly better overall 3- and 5-year survival rates than the conservative treatment group (73.7% and 58.8% vs. 29.8% and 0%, respectively). Although elderly gastric cancer patients show an advanced stage at diagnosis and poor prognosis compared with non-elderly patients, elderly patients with good performance could benefit from curative resection. Thus, the clinical decision whether to undergo curative resection or conservative management should be made on an individualized basis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27942044</pmid><doi>10.1371/journal.pone.0167615</doi><tpages>e0167615</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Age
Age Factors
Aged
Aged, 80 and over
Aging
Cancer
Cancer patients
Cancer therapies
Case studies
Case-Control Studies
Chemotherapy
Classification
Clinical outcomes
Diagnosis
Elderly
Elderly people
Endoscopy
Female
Gastric cancer
Geriatrics
Health aspects
Health care facilities
Health risk assessment
Helicobacter pylori
Humans
Industrialized nations
Life expectancy
Life span
Male
Medical services
Medicine and Health Sciences
Metastasis
Middle Aged
Older people
Patient outcomes
Patients
People and Places
Prognosis
Republic of Korea
Retrospective Studies
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - epidemiology
Stomach Neoplasms - therapy
Surgery
Survival
Survival Rate
title Clinical Characteristics and Outcomes of Gastric Cancer Patients Aged over 80 Years: A Retrospective Case-Control Study
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