Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

• Published in: PloS one 2016-12, Vol.11 (12), p.e0168290-e0168290
• Main Authors: Blanc, Peggy, Dutronc, Hervé, Peuchant, Olivia, Dauchy, Frédéric-Antoine, Cazanave, Charles, Neau, Didier, Wirth, Gaëtane, Pellegrin, Jean-Luc, Morlat, Philippe, Mercié, Patrick, Tunon-de-Lara, José-Manuel, Doutre, Marie-Sylvie, Pélissier, Philippe, Dupon, Michel
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Analysis; Antibiotics; Bacillus Calmette-Guerin vaccine; BCG; Biology and Life Sciences; Child; Child health; Child, Preschool; Children; Diagnosis; Epidemiology; Female; France - epidemiology; HIV; Hospitals, University; Human immunodeficiency virus; Humans; Infant; Infections; Infectious diseases; Laboratories; Life Sciences; Lung - microbiology; Lung diseases; Lung Diseases - microbiology; Lymph nodes; Lymphadenitis; Lymphadenitis - epidemiology; Male; Medical instruments; Medical prognosis; Medicine and Health Sciences; Middle Aged; Mortality; Mycobacterium; Mycobacterium avium; Mycobacterium infections; Mycobacterium Infections, Nontuberculous - epidemiology; Mycobacterium Infections, Nontuberculous - microbiology; Mycobacterium marinum; Nontuberculous Mycobacteria - isolation & purification; Pathogens; Patient Outcome Assessment; Patients; Retrospective Studies; Risk factors; Skin; Thorax; Vaccination; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0168290

Nontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described. We conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. We used the microbiologic component of the American Thoracic Society/Infectious Diseases Society of America's pulmonary NTM disease criteria to define cases of pulmonary NTM, and patients with isolates from a normally sterile site were classified as having extrapulmonary disease. In our setting, 170 patients were included. Pulmonary cases predominated (54.1%), followed by skin and soft tissue infections (22.9%), disseminated cases (10.6%), lymphadenitis (7.7%), bone and joint infections (2.9%) and the remaining 1.8% catheter-related infections. Overall, 16 NTM species were isolated. Mycobacterium avium (31.8%) and M. intracellulare (20%) were the most common species identified, followed by M. marinum (13.5%), M. kansasii (10.6%), M. xenopi (9.4%), rapidly growing mycobacteria (9.4%) and other slowly growing mycobacteria (5.3%). In general, NTM isolates were largely prevalent in people older than 50 (62.4%); patients aged 1-10 year-old exclusively yielded M. avium from lymph nodes, almost cases having being diagnosed after 2007. Among the 121 patients with complete follow-up, 78 (64.5%), 24 (19.8%), and 19 (15.7%) were cured, experienced relapse, or died, respectively. In our study, extrapulmonary NTM infections represented almost half of cases, consisting mainly in skin and soft tissue infections. The increase lymphadenitis cases in children after 2007 could be linked to the cessation of mandatory BCG vaccination in France. We observed similar cure rates (64%) between pulmonary and extrapulmonary infections.