What's the Optimal Lipids Level for Dialysis Patients? A Cohort Study from a Chinese Dialysis Center in a University Hospital

• Published in: PloS one 2016-12, Vol.11 (12), p.e0167258
• Main Authors: Yang, Wen-Ling, Zhu, Xue-Yan, Zhu, Ning, Su, Chun-Yan, Han, Qing-Feng, Wang, Tao, Zhang, Ai-Hua
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis; Biology and Life Sciences; Calcium; Calcium phosphates; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - mortality; Care and treatment; China; Chronic kidney failure; Cohort analysis; Cohort Studies; Comorbidity; Dialysis; Fatalities; Female; Hazards; Health aspects; Health risk assessment; Hemodialysis patients; High density lipoprotein; Hospitals, University; Humans; Ischemia; Lipids; Lipids - blood; Lipoproteins (high density); Lipoproteins (low density); Low density lipoprotein; Low density lipoproteins; Male; Medical prognosis; Medicine and Health Sciences; Metabolic disorders; Middle Aged; Mortality; Nutrition; Patients; People and Places; Physiological aspects; Prognosis; Proportional Hazards Models; Renal Dialysis - adverse effects; Renal Dialysis - mortality; Risk analysis; Risk Factors; Statins; Survival; Survival Analysis; Triglycerides
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0167258

With lipid level being a major contributing factor for cardiovascular health, the high cardiovascular mortality among dialysis patients has raised substantial concerns in regard to the optimal lipid level in these patient population. To explore the optimal lipid level for the survival of dialysis patients. The lipid profile was measured for each patient. All participants were followed throughout the course of the study. Cox proportional hazards analysis was performed to analyze the prognostic value of lipid level on the survival of these patients. In our study that included 311 stable maintenance dialysis patients, 54.98% of the participants had LDL-C level ≥100 mg/dl and 82.91% of the patients with triglycerides ≥200 mg/dl had non-HDL level ≥130 mg/dl. During the follow-up period of 48.0 (18.0, 55.5) months, 149 (47.91%) participants died. Among those who died, 59 patients died of cardiovascular disease (CVD) and 33 patients died of ischemic CVD (12.0, 4.7, and 2.7 events per 100 patient-years, respectively). Patients with LDL-C 100-130 mg/dl or non-HDL 130-160 mg/dl had a lower all-cause mortality rate than those who did not meet these criteria. After adjusting for the traditional and ESRD-related risk factors, non-HDL was found to be the independent risk factor for the all-cause mortality. Compared to those patients with non-HDL 130-160 mg/dl, patients with non-HDL