Downregulation of FBP1 Promotes Tumor Metastasis and Indicates Poor Prognosis in Gastric Cancer via Regulating Epithelial-Mesenchymal Transition

Recent studies indicated that some glycolytic enzymes are complicated, multifaceted proteins rather than simple components of the glycolytic pathway. FBP1 plays a vital role in glucose metabolism, but its role in gastric cancer tumorigenesis and metastasis has not been fully understood. The prognost...

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Bibliographic Details
Published in:PloS one 2016-12, Vol.11 (12), p.e0167857-e0167857
Main Authors: Li, Jing, Wang, Ying, Li, Qing-Guo, Xue, Jin-Jun, Wang, Zhu, Yuan, Xin, Tong, Jian-Dong, Xu, Li-Chun
Format: Article
Language:English
Subjects:
Adult
Aedes
Aged
Aged, 80 and over
Aldolases
Analysis
Apoptosis
Biology and Life Sciences
Blotting, Western
Breast cancer
Cancer
Cancer metastasis
Cancer therapies
Cell growth
Cell Line, Tumor
Cell Movement - genetics
Cell Movement - physiology
Cell proliferation
Chemotherapy
Colorectal cancer
Development and progression
Disease prevention
DNA Helicases - genetics
DNA Helicases - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Enzymes
Epithelial-Mesenchymal Transition - genetics
Epithelial-Mesenchymal Transition - physiology
Female
Gastric cancer
Gene expression
Genetic aspects
Genomes
Glucose metabolism
Glycolysis
Health aspects
Hospitals
Humans
In vitro methods and tests
Inhibition
Male
Medical prognosis
Medical research
Medicine and Health Sciences
Mesenchyme
Metabolism
Metastases
Metastasis
MicroRNAs
Middle Aged
mRNA
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Oncology
Physiological aspects
Prognosis
Proteins
Regression analysis
Research and Analysis Methods
Stomach cancer
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Survival
Tumor suppressor genes
Tumorigenesis
Tumors
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Summary:Recent studies indicated that some glycolytic enzymes are complicated, multifaceted proteins rather than simple components of the glycolytic pathway. FBP1 plays a vital role in glucose metabolism, but its role in gastric cancer tumorigenesis and metastasis has not been fully understood. The prognostic value of FBP1 was first studied in The Cancer Genome Atlas (TCGA) database and validated in in-house database. The effect of FBP1 on cell proliferation and metastasis was examined in vitro. Nonparametric test and Log-rank test were used to evaluate the clinical significance of FBP1 expression. In the TCGA cohort, FBP1 mRNA level were shown to be predictive of overall survival in gastric cancer (P = 0.029). In the validation cohort, FBP1 expression were inversely correlated with advanced N stage (P = 0.021) and lymphovascular invasion (P = 0.011). Multivariate Cox regression analysis demonstrated that FBP1 was an independent predictor for both overall survival (P = 0.004) and disease free survival (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0167857