Impact of Chronic Smoking on Meibomian Gland Dysfunction

The aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD). This study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tea...

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Bibliographic Details
Published in:PloS one 2016-12, Vol.11 (12), p.e0168763-e0168763
Main Authors: Wang, Shen, Zhao, Hui, Huang, Caihong, Li, Zhengri, Li, Wei, Zhang, Xiaobo, Liu, Zuguo
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Analysis
Biology and Life Sciences
Chronic fatigue syndrome
Cigarette smoking
Cigarettes
College campuses
Complications and side effects
Cornea
Correlation analysis
Cytokines
Diabetic retinopathy
Eye diseases
Female
Fluorescein
Hospitals
Humans
Inflammation
Male
Medicine and Health Sciences
Meibomian Glands - drug effects
Meibomian Glands - physiopathology
Middle Aged
Patients
Research and Analysis Methods
Risk factors
Smoking
Smoking - adverse effects
Stains & staining
Tearing
Time Factors
Tobacco
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Summary:The aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD). This study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), Schirmer I test (SIT)and finally slit-lamp microscope examination of lid margin abnormalities, meibomian gland expression as well as meibum. Compared with the MGD patients without smoking, the MGD patients with smoking had significantly increased scores of lid margin abnormality and meibum (P0.05 for each comparison). In the smokers, the smoking index was significantly correlated with the scores of lid margin abnormality (Both sexes, R = 0.19, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0168763