Prediction of Small for Gestational Age Infants in Healthy Nulliparous Women Using Clinical and Ultrasound Risk Factors Combined with Early Pregnancy Biomarkers

Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks'...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0169311-e0169311
Main Authors: McCowan, Lesley M E, Thompson, John M D, Taylor, Rennae S, Baker, Philip N, North, Robyn A, Poston, Lucilla, Roberts, Claire T, Simpson, Nigel A B, Walker, James J, Myers, Jenny, Kenny, Louise C
Format: Article
Language:English
Subjects:
Accuracy
Age
Analysis
Babies
Biological markers
Biology and Life Sciences
Biomarkers
Biometrics
Birth weight
Confidence intervals
Consortia
Data processing
Datasets
Doppler effect
Female
Fetuses
Gestation
Gestational Age
Growth factors
Gynecology
Health aspects
Health risk assessment
Health screening
Humans
Hypertension
Infant, Small for Gestational Age - metabolism
Infants
Mathematical models
Medicine and Health Sciences
Morbidity
Obstetrics
Parity
People and Places
Physical Sciences
Prediction models
Preeclampsia
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Third
Premature birth
Prenatal development
Prognosis
Regression analysis
Research and Analysis Methods
Risk analysis
Risk Factors
Screening
Small-for-gestational age
Statistical analysis
Systematic review
Training
Ultrasonography, Prenatal
Ultrasound
Veins & arteries
Womens health
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Summary:Most small for gestational age pregnancies are unrecognised before birth, resulting in substantial avoidable perinatal mortality and morbidity. Our objective was to develop multivariable prediction models for small for gestational age combining clinical risk factors and biomarkers at 15±1 weeks' with ultrasound parameters at 20±1 weeks' gestation. Data from 5606 participants in the Screening for Pregnancy Endpoints (SCOPE) cohort study were divided into Training (n = 3735) and Validation datasets (n = 1871). The primary outcomes were All-SGA (small for gestational age with birthweight
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0169311