Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid prod...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0169824-e0169824
Main Authors: Jung, Yu Ra, Lee, Jin-Hyup, Sohn, Kyung-Cheol, Lee, Young, Seo, Young-Joon, Kim, Chang-Deok, Lee, Jeung-Hoon, Hong, Seung-Phil, Seo, Seong-Jun, Kim, Seong-Jin, Im, Myung
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - biosynthesis
Asthma
Atopic dermatitis
Biology and Life Sciences
Bodily secretions
Cell culture
Cell proliferation
Cells, Cultured
Cellular proteins
Cellular signal transduction
Chromatography
Dermatitis
Dermatology
Eczema
Female
Genetic aspects
Glands
Glycerol
Homeostasis
Humans
Hydration
Immunoglobulins
In vivo methods and tests
Kinases
Lipid synthesis
Lipids
Lipogenesis
Lipogenesis - physiology
Male
Medicine
Medicine and Health Sciences
Properties
Psoriasis
Research and Analysis Methods
Rodents
Sebaceous gland
Sebaceous glands
Sebaceous Glands - cytology
Sebaceous Glands - metabolism
Signal Transduction - physiology
Signaling
Skin
Thin layer chromatography
Tissues
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Summary:Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that human sebaceous glands in vivo and sebocytes in vitro express adiponectin receptor and that adiponectin increased cell proliferation. Moreover, based on a lipogenesis study using Oil Red O, Nile red staining and thin layer chromatography, adiponectin strongly upregulated lipid production in sebocytes. In three-dimensional culture of sebocytes, lipid synthesis was markedly enhanced in sebocytes treated with adiponectin. This study suggested that adiponectin plays a significant role in human sebaceous gland biology. Adiponectin signaling is a promising target in the clinical management of barrier disorders in which sebum production is decreased, such as in atopic dermatitis and aged skin.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0169824