Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. Between 2005 and 2012, 51 ACL (cases) and 51 temporally matc...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2016-12, Vol.10 (12), p.e0005100-e0005100
Main Authors: Guimarães, Luiz Henrique, Queiroz, Adriano, Silva, Juliana A, Silva, Silvana C, Magalhães, Viviane, Lago, Ednaldo L, Machado, Paulo Roberto L, Bacellar, Olívia, Wilson, Mary E, Beverley, Stephen M, Carvalho, Edgar M, Schriefer, Albert
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis
Antigens
Antimony
Biology and Life Sciences
Brazil - epidemiology
Care and treatment
Colleges & universities
Cutaneous leishmaniasis
Cytokines
Diagnosis
Endemic Diseases
Female
Funding
Genotypes
Hospitals
Humans
Immunology
Interferon-gamma - genetics
Interferon-gamma - immunology
Interleukin-17 - genetics
Interleukin-17 - immunology
Leishmania braziliensis - genetics
Leishmania braziliensis - isolation & purification
Leishmania braziliensis - physiology
Leishmaniasis, Cutaneous - epidemiology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - parasitology
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - parasitology
Male
Medicine and Health Sciences
Middle Aged
Parasites
Parasitic diseases
Pathogenesis
People and places
Physical Sciences
Physiological aspects
Polymorphism, Single Nucleotide
Tropical diseases
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - immunology
Vector-borne diseases
Young Adult
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Summary:Atypical cutaneous leishmaniasis (ACL) has become progressively more frequent in Corte de Pedra, Northeast Brazil. Herein we characterize clinical presentation, antimony response, cytokine production and parasite strains prevailing in ACL. Between 2005 and 2012, 51 ACL (cases) and 51 temporally matched cutaneous leishmaniasis (CL) subjects (controls) were enrolled and followed over time in Corte de Pedra. Clinical and therapeutic data were recorded for all subjects. Cytokine secretion by patients' peripheral blood mononuclear cells (PBMC) stimulated with soluble parasite antigen in vitro, and genotypes in a 600 base-pair locus in chromosome 28 (CHR28/425451) of the infecting L. (V.) braziliensis were compared between the two groups. ACL presented significantly more lesions in head and neck, and higher rate of antimony failure than CL. Cytosine-Adenine substitutions at CHR28/425451 positions 254 and 321 were highly associated with ACL (p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0005100