Does Antiplatelet Therapy during Bridging Thrombolysis Increase Rates of Intracerebral Hemorrhage in Stroke Patients?

Symptomatic intracerebral hemorrhage (sICH) after bridging thrombolysis for acute ischemic stroke is a devastating complication. We aimed to assess whether the additional administration of aspirin during endovascular intervention increases bleeding rates. We retrospectively compared bleeding complic...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0170045-e0170045
Main Authors: Broeg-Morvay, Anne, Mordasini, Pasquale, Slezak, Agnieszka, Liesirova, Kai, Meisterernst, Julia, Schroth, Gerhard, Arnold, Marcel, Jung, Simon, Mattle, Heinrich P, Gralla, Jan, Fischer, Urs
Format: Article
Language:English
Subjects:
Aged
Analysis
Angioplasty
Antiplatelet therapy
Aspirin
Biology and Life Sciences
Bleeding
Blood clots
Bridging
Cardiovascular system
Carotid arteries
Carotid artery
Catheters
Cerebral blood flow
Cerebral Hemorrhage - drug therapy
Cerebral Hemorrhage - etiology
Complications
Complications and side effects
Dosage and administration
Drug therapy
Drugs
Female
Health aspects
Heart attacks
Hemorrhage
Humans
Intervention
Intracerebral hemorrhage
Ischemia
Laboratories
Male
Medical imaging
Medicine and Health Sciences
Neurology
Occlusion
Patients
Platelet aggregation inhibitors
Platelet Aggregation Inhibitors - therapeutic use
Prospective Studies
Regression analysis
Retrospective Studies
Risk factors
Statistical analysis
Stents
Stroke
Stroke - complications
Stroke patients
Therapy
Thrombolysis
Thrombolytic Therapy
Thrombosis
Treatment outcome
Veins & arteries
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Summary:Symptomatic intracerebral hemorrhage (sICH) after bridging thrombolysis for acute ischemic stroke is a devastating complication. We aimed to assess whether the additional administration of aspirin during endovascular intervention increases bleeding rates. We retrospectively compared bleeding complications and outcome in stroke patients who received bridging thrombolysis with (tPA+ASA) and without (tPA-ASA) aspirin during endovascular intervention between November 2008 and March 2014. Furthermore, we analyzed bleeding complications and outcome in antiplatelet naïve patients with those with prior or acute antiplatelet therapy. Baseline characteristics, previous medication, and dosage of rtPA did not differ between 50 tPA+ASA (39 aspirin naïve, 11 preloaded) and 181 tPA-ASA patients (p>0.05). tPA+ASA patients had more often internal carotid artery (ICA) occlusion (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0170045