Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buff...

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Bibliographic Details
Published in:PloS one 2017, Vol.12 (1), p.e0170545-e0170545
Main Authors: Winerdal, Max, Urmaliya, Vijay, Winerdal, Malin E, Fredholm, Bertil B, Winqvist, Ola, Ådén, Ulrika
Format: Article
Language:English
Subjects:
Adenosine
Animals
Animals, Newborn
Biology and Life Sciences
Brain
Brain injury
Caffeine
Caffeine - administration & dosage
Carotid arteries
Disease Models, Animal
Dosage and administration
Dose-Response Relationship, Drug
Drug dosages
Flow cytometry
Head injuries
Health aspects
Humans
Hypoxia
Hypoxia-Ischemia, Brain - drug therapy
Hypoxia-Ischemia, Brain - pathology
Immune response
Immunoglobulins
Immunology
Ischemia
Medicin och hälsovetenskap
Medicine and Health Sciences
Mice
Neonates
Neurons - drug effects
Neurons - pathology
Neuroprotection
Neuroprotective Agents - administration & dosage
Newborn babies
Newborn infants
Phosphates
Physical Sciences
Physiology
Prevention
Research and Analysis Methods
Rodents
Studies
Traumatic brain injury
Treatment Outcome
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Description
Summary:In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0170545