Association between Allogeneic or Autologous Blood Transfusion and Survival in Patients after Radical Prostatectomy: A Systematic Review and Meta-Analysis

A number of studies have investigated the effect of perioperative blood transfusion (PBT) for patients after radical prostatectomy (RP), with some reporting conflicting results. A systematic review of the literature and a meta-analysis were conducted to explore the association between PBT (autologou...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0171081-e0171081
Main Authors: Li, Su-Liang, Ye, Yun, Yuan, Xiao-Hua
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood
Blood transfusion
Blood Transfusion, Autologous
Blood transfusions
Cancer
Cancer surgery
Care and treatment
Complications and side effects
Confidence intervals
Conservation
Data analysis
Data processing
Disease-Free Survival
Handbooks
Hospitals
Humans
Laboratories
Literature reviews
Male
Medical ethics
Medical prognosis
Medicine and Health Sciences
Meta-analysis
Models, Theoretical
Mortality
Neoplasm Recurrence, Local - pathology
Patient outcomes
Patients
Physical Sciences
Polybutylene terephthalates
Prostate cancer
Prostatectomy
Prostatic Neoplasms - surgery
Prostatic Neoplasms - therapy
Publication Bias
Quality
Research and Analysis Methods
Studies
Surgery
Survival
Systematic review
Transfusion
Transplantation, Homologous
Treatment Outcome
Urological surgery
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Summary:A number of studies have investigated the effect of perioperative blood transfusion (PBT) for patients after radical prostatectomy (RP), with some reporting conflicting results. A systematic review of the literature and a meta-analysis were conducted to explore the association between PBT (autologous or allogeneic) and biochemical recurrence-free survival (BRFS), overall survival (OS) and cancer-specific survival (CSS) in patients undergoing RP. The PubMed, Medline, Cochrane Library, and Embase databases were searched for published controlled clinical studies on perioperative allogeneic or autologous blood transfusion (BT) and patient survival after RP. STATA software version 12.0 was used for data analysis. We used hazard ratios (HRs) and 95% confidence intervals (CIs) to test the correlation between BT and patient survival after RP. Data from a total of 26,698 patients in ten published studies were included in the meta-analysis. The meta-analysis results showed that autologous BT was not associated with BRFS (HR: 1.06; 95% CI: 0.96-1.18; Z = 1.17; P = 0.24), OS (HR: 0.86; 95% CI: 0.71-1.04; Z = 1.58; P = 0.11), or CSS (HR: 0.98; 95% CI: 0.49-1.96; Z = 0.05; P = 0.96). Allogeneic BT exhibited a significant association with worse BRFS (HR: 1.09; 95% CI: 1.01-1.16; Z = 2.37; P = 0.02), OS (HR: 1.43; 95% CI: 1.24-1.64; Z = 4.95; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0171081