Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses

While it is likely that both induced endocytosis and active penetration occur during OPC, it has been difficult to determine the role of active penetration in the pathogenesis of OPC because most invasins are hyphal specific. [...]C. albicans mutants that do not form hyphae also fail to express inva...

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Bibliographic Details
Published in:PLoS pathogens 2017-01, Vol.13 (1), p.e1006056-e1006056
Main Authors: Swidergall, Marc, Filler, Scott G
Format: Article
Language:English
Subjects:
Antifungal agents
Bacteria
Biofilms
Biology and Life Sciences
Biomedical research
Candidiasis
Candidiasis, Oral - immunology
Candidiasis, Oral - microbiology
Care and treatment
Cytokines
Dosage and administration
Epidermal growth factor
Epithelial cells
Epithelial Cells - immunology
Fungal infections
Fungi
Health aspects
HIV patients
Humans
Immunity, Mucosal - immunology
Immunosuppressive agents
Infectious diseases
Medicine and Health Sciences
Mouth Mucosa - immunology
Mouth Mucosa - microbiology
Organisms
Pathogenesis
Pearls
Peptides
Proteins
Research and Analysis Methods
Staphylococcus infections
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Summary:While it is likely that both induced endocytosis and active penetration occur during OPC, it has been difficult to determine the role of active penetration in the pathogenesis of OPC because most invasins are hyphal specific. [...]C. albicans mutants that do not form hyphae also fail to express invasins and, consequently, are defective in both active penetration and induced endocytosis. Recently, it has been found that C. albicans infection also stimulates the activity of epithelial cell calpain, a cysteine protease that degrades E-cadherin. [...]calpain activity is dramatically enhanced in epithelial cells that are co-infected with C. albicans and Streptococcus oralis [10].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006056