Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study

Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with lo...

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Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0173695-e0173695
Main Authors: Santos, Betânia Rodrigues, Lecke, Sheila Bünecker, Spritzer, Poli Mara
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Binding
Binding proteins
Biology and Life Sciences
Blood pressure
Body mass
Body mass index
Body size
Brazil
Calcifediol - blood
Case-Control Studies
Complications and side effects
Cross-Sectional Studies
Female
Genetic aspects
Genetic diversity
Genetic variance
Genotype
Genotypes
Haplotypes
Humans
Insulin
Insulin Resistance
Medicine and Health Sciences
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Obesity
Physical sciences
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - genetics
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical analysis
Teenagers
Vitamin D
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - etiology
Vitamin D-binding protein
Vitamin D-Binding Protein - genetics
Vitamin deficiency
Womens health
Young Adult
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Summary:Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Therefore, we determined the genotype and haplotype distribution of DBP gene polymorphisms and investigated the associations between these genetic variants and their haplotypes with PCOS, MetS, and 25(OH)D levels in women with PCOS and controls from the South of Brazil. The sample included 291 women (191 with PCOS and 100 controls). All participants were genotyped for polymorphisms rs2282679, rs4588, and rs7041. Serum 25(OH)D levels were determined in a subset of 102 participants. Women with PCOS were younger and had significantly higher body mass index, blood pressure, and insulin resistance than the control group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0173695