Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study

Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with lo...

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Published in:PloS one 2017-03, Vol.12 (3), p.e0173695-e0173695
Main Authors: Santos, Betânia Rodrigues, Lecke, Sheila Bünecker, Spritzer, Poli Mara
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adult
Binding
Binding proteins
Biology and Life Sciences
Blood pressure
Body mass
Body mass index
Body size
Brazil
Calcifediol - blood
Case-Control Studies
Complications and side effects
Cross-Sectional Studies
Female
Genetic aspects
Genetic diversity
Genetic variance
Genotype
Genotypes
Haplotypes
Humans
Insulin
Insulin Resistance
Medicine and Health Sciences
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Obesity
Physical sciences
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - genetics
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical analysis
Teenagers
Vitamin D
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - etiology
Vitamin D-binding protein
Vitamin D-Binding Protein - genetics
Vitamin deficiency
Womens health
Young Adult
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Lecke, Sheila Bünecker
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description Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Therefore, we determined the genotype and haplotype distribution of DBP gene polymorphisms and investigated the associations between these genetic variants and their haplotypes with PCOS, MetS, and 25(OH)D levels in women with PCOS and controls from the South of Brazil. The sample included 291 women (191 with PCOS and 100 controls). All participants were genotyped for polymorphisms rs2282679, rs4588, and rs7041. Serum 25(OH)D levels were determined in a subset of 102 participants. Women with PCOS were younger and had significantly higher body mass index, blood pressure, and insulin resistance than the control group (p
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The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Therefore, we determined the genotype and haplotype distribution of DBP gene polymorphisms and investigated the associations between these genetic variants and their haplotypes with PCOS, MetS, and 25(OH)D levels in women with PCOS and controls from the South of Brazil. The sample included 291 women (191 with PCOS and 100 controls). All participants were genotyped for polymorphisms rs2282679, rs4588, and rs7041. Serum 25(OH)D levels were determined in a subset of 102 participants. Women with PCOS were younger and had significantly higher body mass index, blood pressure, and insulin resistance than the control group (p&lt;0.05). The prevalence of MetS in PCOS and controls was 26.5% and 4.8% respectively. Levels of 25(OH)D were lower in PCOS women with MetS, even after adjustment for age (p = 0.033). No associations were observed between PCOS and the polymorphisms or their haplotypes. A higher frequency of genotype TT of rs7041 was found in PCOS participants with MetS (OR: 2.21, 95%CI:1.08-4.52; p = 0.027). This same genotype was associated with lower 25(OH)D levels in both PCOS and control women (OR: 4.40, 95%CI:1.62-12.00; p = 0.002). In conclusion, these findings indicate that DBP gene polymorphisms and their haplotypes are not directly associated with PCOS. In contrast, the TT genotype of SNP rs7041 was associated with MetS in PCOS women, and with lower 25(OH)D levels in both PCOS and control groups.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0173695</identifier><identifier>PMID: 28278285</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; Adult ; Binding ; Binding proteins ; Biology and Life Sciences ; Blood pressure ; Body mass ; Body mass index ; Body size ; Brazil ; Calcifediol - blood ; Case-Control Studies ; Complications and side effects ; Cross-Sectional Studies ; Female ; Genetic aspects ; Genetic diversity ; Genetic variance ; Genotype ; Genotypes ; Haplotypes ; Humans ; Insulin ; Insulin Resistance ; Medicine and Health Sciences ; Metabolic syndrome ; Metabolic Syndrome - blood ; Metabolic Syndrome - etiology ; Obesity ; Physical sciences ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - genetics ; Polymorphism, Single Nucleotide - genetics ; Risk Factors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Statistical analysis ; Teenagers ; Vitamin D ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - etiology ; Vitamin D-binding protein ; Vitamin D-Binding Protein - genetics ; Vitamin deficiency ; Womens health ; Young Adult</subject><ispartof>PloS one, 2017-03, Vol.12 (3), p.e0173695-e0173695</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Santos et al. 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The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Therefore, we determined the genotype and haplotype distribution of DBP gene polymorphisms and investigated the associations between these genetic variants and their haplotypes with PCOS, MetS, and 25(OH)D levels in women with PCOS and controls from the South of Brazil. The sample included 291 women (191 with PCOS and 100 controls). All participants were genotyped for polymorphisms rs2282679, rs4588, and rs7041. Serum 25(OH)D levels were determined in a subset of 102 participants. Women with PCOS were younger and had significantly higher body mass index, blood pressure, and insulin resistance than the control group (p&lt;0.05). 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Betânia Rodrigues</au><au>Lecke, Sheila Bünecker</au><au>Spritzer, Poli Mara</au><au>Yu, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-03-09</date><risdate>2017</risdate><volume>12</volume><issue>3</issue><spage>e0173695</spage><epage>e0173695</epage><pages>e0173695-e0173695</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Vitamin D deficiency has been related to metabolic syndrome (MetS) in polycystic ovary syndrome (PCOS). The vitamin D-binding protein (DBP) is the main protein involved in vitamin D transport. Two single-nucleotide polymorphisms (SNPs) of the DBP gene, rs4588 and rs7041, have been associated with low circulating levels of 25-hydroxyvitamin D [25(OH)D] in various populations, but not in women with PCOS. Therefore, we determined the genotype and haplotype distribution of DBP gene polymorphisms and investigated the associations between these genetic variants and their haplotypes with PCOS, MetS, and 25(OH)D levels in women with PCOS and controls from the South of Brazil. The sample included 291 women (191 with PCOS and 100 controls). All participants were genotyped for polymorphisms rs2282679, rs4588, and rs7041. Serum 25(OH)D levels were determined in a subset of 102 participants. Women with PCOS were younger and had significantly higher body mass index, blood pressure, and insulin resistance than the control group (p&lt;0.05). The prevalence of MetS in PCOS and controls was 26.5% and 4.8% respectively. Levels of 25(OH)D were lower in PCOS women with MetS, even after adjustment for age (p = 0.033). No associations were observed between PCOS and the polymorphisms or their haplotypes. A higher frequency of genotype TT of rs7041 was found in PCOS participants with MetS (OR: 2.21, 95%CI:1.08-4.52; p = 0.027). This same genotype was associated with lower 25(OH)D levels in both PCOS and control women (OR: 4.40, 95%CI:1.62-12.00; p = 0.002). In conclusion, these findings indicate that DBP gene polymorphisms and their haplotypes are not directly associated with PCOS. In contrast, the TT genotype of SNP rs7041 was associated with MetS in PCOS women, and with lower 25(OH)D levels in both PCOS and control groups.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28278285</pmid><doi>10.1371/journal.pone.0173695</doi><tpages>e0173695</tpages><orcidid>https://orcid.org/0000-0002-6734-7688</orcidid><oa>free_for_read</oa></addata></record>
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issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1875828313
source Open Access: PubMed Central; Publicly Available Content Database
subjects 25-Hydroxyvitamin D
Adult
Binding
Binding proteins
Biology and Life Sciences
Blood pressure
Body mass
Body mass index
Body size
Brazil
Calcifediol - blood
Case-Control Studies
Complications and side effects
Cross-Sectional Studies
Female
Genetic aspects
Genetic diversity
Genetic variance
Genotype
Genotypes
Haplotypes
Humans
Insulin
Insulin Resistance
Medicine and Health Sciences
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Obesity
Physical sciences
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - genetics
Polymorphism, Single Nucleotide - genetics
Risk Factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Statistical analysis
Teenagers
Vitamin D
Vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - etiology
Vitamin D-binding protein
Vitamin D-Binding Protein - genetics
Vitamin deficiency
Womens health
Young Adult
title Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study
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