IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells

γδ T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human γδ T lymphocytes express a Vγ9Vδ2+ (Vδ2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFNγ, produced by Vδ2+ cells,...

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Bibliographic Details
Published in:PloS one 2017-01, Vol.12 (1), p.e0169362-e0169362
Main Authors: Fechter, Karoline, Dorronsoro, Akaitz, Jakobsson, Emma, Ferrin, Izaskun, Lang, Valérie, Sepulveda, Pilar, Pennington, Daniel J, Trigueros, César
Format: Article
Language:English
Subjects:
Adipocytes
Amino acids
Autoimmune diseases
Autoimmunity
Biology and Life Sciences
Bone marrow
Bone Marrow Cells - drug effects
Bone Marrow Cells - physiology
Cancer
Cell activation
Cell growth
Cell Proliferation - drug effects
Cells, Cultured
Cytokines
Dendritic cells
Dioxygenase
Disease
Feedback
Feedback, Physiological - drug effects
Genetic modification
Growth factors
Humans
Immune system
Immune Tolerance - drug effects
Immunology
Immunoregulation
Immunosuppression
Inflammation
Interferon-gamma - pharmacology
Laboratories
Lupus
Lymphocyte Activation - drug effects
Lymphocytes
Lymphocytes T
Medical research
Medicine and Health Sciences
Mesenchymal stem cells
Mesenchymal Stromal Cells - drug effects
Mesenchymal Stromal Cells - physiology
Mesenchyme
Negative feedback
Pathogenesis
Penicillin
Psoriasis
Receptors, Antigen, T-Cell, gamma-delta - metabolism
Research and Analysis Methods
Rheumatoid arthritis
Signal Transduction - drug effects
Signal Transduction - immunology
Stem cells
T cell receptors
T-cell receptor
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Transplants & implants
Tryptophan
γ-Interferon
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Summary:γδ T cells play a role in a wide range of diseases such as autoimmunity and cancer. The majority of circulating human γδ T lymphocytes express a Vγ9Vδ2+ (Vδ2+) T cell receptor (TCR) and following activation release pro-inflammatory cytokines. In this study, we show that IFNγ, produced by Vδ2+ cells, activates mesenchymal stem cell (MSC)-mediated immunosupression, which in turn exerts a negative feedback mechanism on γδ T cell function ranging from cytokine production to proliferation. Importantly, this modulatory effect is limited to a short period of time (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0169362