Evaluations of primary lesions by endoscopy clearly distinguishes prognosis in patients with gastric cancer who receive chemotherapy

Chemotherapy may improve outcomes in gastric cancer (GC), especially for the patients with advanced stage. To explore useful predictive factor for GC performing chemotherapy, we compared the tumor responses assessed using computed tomography (CT) with endoscopy based criteria. 192 GC patients perfor...

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Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0173663-e0173663
Main Authors: Tahara, Tomomitsu, Shibata, Tomoyuki, Okubo, Masaaki, Kawamura, Tomohiko, Horiguchi, Noriyuki, Yoshida, Dai, Ishizuka, Takamitsu, Nagasaka, Mitsuo, Nakagawa, Yoshihito, Ohmiya, Naoki
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biology and Life Sciences
Biopsy
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Computed tomography
Confidence intervals
Disease
Disease-Free Survival
Endoscopy
Evaluation
Feasibility studies
Female
Gastric cancer
Gastroenterology
Gastroscopy - methods
Humans
Lesions
Lymphatic system
Male
Medical imaging
Medical prognosis
Medicine
Medicine and Health Sciences
Metabolism
Metastasis
Middle Aged
Neoadjuvant Therapy
Patients
Performance prediction
Peritoneum
Prognosis
Regression analysis
Regression models
Research and Analysis Methods
Retrospective Studies
Statistical analysis
Stomach cancer
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - drug therapy
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Survival
Tomography
Tomography, X-Ray Computed - methods
Treatment Outcome
Tumors
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Summary:Chemotherapy may improve outcomes in gastric cancer (GC), especially for the patients with advanced stage. To explore useful predictive factor for GC performing chemotherapy, we compared the tumor responses assessed using computed tomography (CT) with endoscopy based criteria. 192 GC patients performing chemotherapy were retrospectively studied. CT based response assessment was performed after 2 courses of treatment. Endoscopic evaluation according to The Japanese classification of gastric carcinoma was also performed at same period. Data were correlated with overall survival (OS) and progression-free survival (PFS). Majority of the cases (n = 178, 93%) received S-1 based chemotherapy as the first line treatment. 55 (29%) and 91 (47%) cases were considered to be CT and endoscopic responders. Endoscopic responder was more clearly associated with better OS and PFS compared to CT based responder by the log-rank test (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0173663