Specific changes in circulating cytokines and growth factors induced by exercise stress testing in asymptomatic aortic valve stenosis

• Published in: PloS one 2017-03, Vol.12 (3), p.e0173787-e0173787
• Main Authors: Kolasa-Trela, Renata, Konieczynska, Malgorzata, Bazanek, Marta, Undas, Anetta
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Angiogenesis; Aorta; Aortic valve; Aortic valve stenosis; Aortic Valve Stenosis - physiopathology; Atherosclerosis; Bicycles; Biology and Life Sciences; Calcification; Cardiovascular disease; Coronary vessels; Cytokines; Cytokines - blood; Endothelium; Exercise; Exercise Test; Female; Genetic aspects; Growth factors; Health aspects; Heart rate; Hepatocyte growth factor; Hospitals; Humans; Hypertension; Inflammation; Intercellular Signaling Peptides and Proteins - blood; Interleukin 10; Interleukin 6; Male; Medicine and Health Sciences; Middle Aged; Mineralization; Patients; Physical fitness; Physical training; Plasma levels; Rheumatic heart disease; Shear stress; Stenosis; Studies; Transforming growth factor; Tumor necrosis factor-TNF; Vascular endothelial growth factor; Workloads; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0173787

We evaluated exercise-induced changes in the profile of circulating cytokines and growth factors in patients with AS. We studied 32 consecutive asymptomatic moderate-to-severe AS patients and 32 age and sex-matched controls. Plasma levels of interleukin (IL)-6, IL-10, hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor (TGF)-β were measured at 4 time points, i.e. at rest, at peak bicycle exercise, one hour and 24 hours after a symptom-limited exercise. Exercise increased all the 5 markers in both groups (all p