Gaze-informed, task-situated representation of space in primate hippocampus during virtual navigation

To elucidate how gaze informs the construction of mental space during wayfinding in visual species like primates, we jointly examined navigation behavior, visual exploration, and hippocampal activity as macaque monkeys searched a virtual reality maze for a reward. Cells sensitive to place also respo...

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Published in:PLoS biology 2017-02, Vol.15 (2), p.e2001045-e2001045
Main Authors: Wirth, Sylvia, Baraduc, Pierre, Planté, Aurélie, Pinède, Serge, Duhamel, Jean-René
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal
Biology and Life Sciences
Cognitive science
Computer and Information Sciences
Data collection
Editing
Engineering and Technology
Eye movements
Fixation, Ocular - physiology
Funding
Hippocampus (Brain)
Hippocampus - physiology
Macaca
Macaca mulatta
Medicine and Health Sciences
Neural circuitry
Neuroscience
Neurosciences
Physiological aspects
Primates
Rodents
Social Sciences
Software
Space Perception - physiology
Spatial Navigation - physiology
Studies
Task Performance and Analysis
Virtual reality
Visual Pathways
Writing
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description To elucidate how gaze informs the construction of mental space during wayfinding in visual species like primates, we jointly examined navigation behavior, visual exploration, and hippocampal activity as macaque monkeys searched a virtual reality maze for a reward. Cells sensitive to place also responded to one or more variables like head direction, point of gaze, or task context. Many cells fired at the sight (and in anticipation) of a single landmark in a viewpoint- or task-dependent manner, simultaneously encoding the animal's logical situation within a set of actions leading to the goal. Overall, hippocampal activity was best fit by a fine-grained state space comprising current position, view, and action contexts. Our findings indicate that counterparts of rodent place cells in primates embody multidimensional, task-situated knowledge pertaining to the target of gaze, therein supporting self-awareness in the construction of space.
doi_str_mv 10.1371/journal.pbio.2001045
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subjects Animals
Behavior, Animal
Biology and Life Sciences
Cognitive science
Computer and Information Sciences
Data collection
Editing
Engineering and Technology
Eye movements
Fixation, Ocular - physiology
Funding
Hippocampus (Brain)
Hippocampus - physiology
Macaca
Macaca mulatta
Medicine and Health Sciences
Neural circuitry
Neuroscience
Neurosciences
Physiological aspects
Primates
Rodents
Social Sciences
Software
Space Perception - physiology
Spatial Navigation - physiology
Studies
Task Performance and Analysis
Virtual reality
Visual Pathways
Writing
title Gaze-informed, task-situated representation of space in primate hippocampus during virtual navigation
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