Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease

Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic fibrogenesis. Diagnostic performance of these markers for non-invasive liver fibrosis prediction was evaluated based on liver histology and stiff...

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Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0173506-e0173506
Main Authors: Krawczyk, Marcin, Zimmermann, Simone, Hess, Georg, Holz, Robert, Dauer, Marc, Raedle, Jochen, Lammert, Frank, Grünhage, Frank
Format: Article
Language:English
Subjects:
Algorithms
Biology and Life Sciences
Biomarkers - blood
Chronic Disease
Cirrhosis
Cohort Studies
Diagnosis
Diagnostic systems
Fibrosis
Growth factors
Hepatitis
Hepatitis C virus
Hepatology
Histology
Humans
Liver
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver diseases
Liver Diseases - blood
Liver Diseases - pathology
Markers
Medicine
Medicine and Health Sciences
Patients
Physical Sciences
Placenta
Prospective Studies
Regression analysis
Research and Analysis Methods
Risk factors
Rodents
Stiffness
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Summary:Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic fibrogenesis. Diagnostic performance of these markers for non-invasive liver fibrosis prediction was evaluated based on liver histology and stiffness. In total 834 patients were recruited. Receiver-operating-characteristics were used to define cut-offs for markers correlating to fibrosis stages. Odds-ratios were calculated for the presence/absence of fibrosis/cirrhosis and confirmed in the sub-group of patients phenotyped by elastography only. Logistic and uni- and multivariate regression analyses were used to test for association of markers with liver fibrosis stages and for independent prediction of liver histology and stiffness. Marker concentrations correlated significantly (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0173506