Establishing a small animal model for evaluating protective immunity against mumps virus

Although mumps vaccines have been used for several decades, protective immune correlates have not been defined. Recently, mumps outbreaks have occurred in vaccinated populations. To better understand the causes of the outbreaks and to develop means to control outbreaks in mumps vaccine immunized pop...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2017-03, Vol.12 (3), p.e0174444-e0174444
Main Authors: Pickar, Adrian, Xu, Pei, Elson, Andrew, Zengel, James, Sauder, Christian, Rubin, Steve, He, Biao
Format: Article
Language:English
Subjects:
Analysis
Animals
Antibodies, Viral - immunology
Antibodies, Viral - metabolism
Biology and Life Sciences
Cercopithecus aethiops
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Health aspects
Immunity
Immunization
Immunoglobulin G - metabolism
Infections
Interferon
Kinetics
Measles-mumps-rubella vaccines
Medicine and Health Sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Models, Animal
Mumps
Mumps - immunology
Mumps - metabolism
Mumps - prevention & control
Mumps - virology
Mumps virus - immunology
Mumps virus - pathogenicity
Outbreaks
Populations
Prevention
Receptor, Interferon alpha-beta - genetics
Receptor, Interferon alpha-beta - metabolism
Research and Analysis Methods
Rodents
Vaccines
Vero Cells
Veterinary colleges
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although mumps vaccines have been used for several decades, protective immune correlates have not been defined. Recently, mumps outbreaks have occurred in vaccinated populations. To better understand the causes of the outbreaks and to develop means to control outbreaks in mumps vaccine immunized populations, defining protective immune correlates will be critical. Unfortunately, no small animal model for assessing mumps immunity exists. In this study, we evaluated use of type I interferon (IFN) alpha/beta receptor knockout mice (IFN-α/βR-/-) for such a model. We found these mice to be susceptible to mumps virus administered intranasally and intracranially. Passive transfer of purified IgG from immunized mice protected naïve mice from mumps virus infection, confirming the role of antibody in protection and demonstrating the potential for this model to evaluate mumps immunity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0174444