Functional relevance for associations between osteoporosis and genetic variants

Osteoporosis is characterized by increased bone loss and deterioration of bone microarchitecture, which will lead to reduced bone strength and increased risk of fragility fractures. Previous studies have identified many genetic loci associated with osteoporosis, but functional mechanisms underlying...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0174808-e0174808
Main Authors: Liu, Kun, Tan, Li-Jun, Wang, Peng, Chen, Xiang-Ding, Zhu, Li-Hua, Zeng, Qin, Hu, Yuan, Deng, Hong-Wen
Format: Article
Language:English
Subjects:
Affinity
Aging
Apoptosis
Association analysis
Biochemistry
Biocompatibility
Bioinformatics
Biology and Life Sciences
Biotechnology
Bone density
Bone Density - genetics
Bone mass
Bone mineral density
Bone strength
Cell differentiation
Cell lines
Cell survival
Computer programs
Databases, Genetic
Datasets as Topic
Deoxyribonucleic acid
Developing countries
Differentiation
DNA
Environmental health
Fatty acids
Female
Fractures
Gene expression
Gene Expression Profiling
Gene regulation
Genetic aspects
Genetic control
Genetic variance
Genetics
Genomes
Genomics
Genotype & phenotype
Health aspects
Health care
Hip
Human performance
Humans
Imaging techniques
Immunology
In vivo methods and tests
Laboratories
LDCs
Life sciences
Lymphocytes
Lymphocytes B
Mathematical models
Medicine
Medicine and Health Sciences
Metabolic disorders
Metabolism
Older people
Osteoclastogenesis
Osteoporosis
Osteoporosis - genetics
Osteoprogenitor cells
Polymorphism
Polymorphism, Single Nucleotide
Preventive medicine
Proteins
Public health
Quality of life
Quantitative Trait Loci
Rhenium
Risk
Single nucleotide polymorphisms
Statistical analysis
Statistics
Stem cells
Studies
Tissues
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Summary:Osteoporosis is characterized by increased bone loss and deterioration of bone microarchitecture, which will lead to reduced bone strength and increased risk of fragility fractures. Previous studies have identified many genetic loci associated with osteoporosis, but functional mechanisms underlying the associations have rarely been explored. In order to explore the potential molecular functional mechanisms underlying the associations for osteoporosis, we performed integrative analyses by using the publically available datasets and resources. We searched 128 identified osteoporosis associated SNPs (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0174808