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Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children
The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with l...
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| Published in: | PloS one 2017-04, Vol.12 (4), p.e0174691-e0174691 |
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| creator | Yao, Tsung-Chieh Tsai, Hui-Ju Chang, Su-Wei Chung, Ren-Hua Hsu, Jing-Ya Tsai, Ming-Han Liao, Sui-Ling Hua, Man-Chin Lai, Shen-Hao Chen, Li-Chen Yeh, Kuo-Wei Tseng, Yu-Lun Lin, Wan-Chen Chang, Su-Ching Huang, Jing-Long |
| description | The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy.
We investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy.
There were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P |
| doi_str_mv | 10.1371/journal.pone.0174691 |
| format | article |
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We investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy.
There were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P<0.001), after controlling for confounders. The beta coefficient for FEV1 (0.084) was smaller than that for FVC (0.111). In contrast, a negative association was found between BMI z-score and FEV1/FVC ratio (P<0.001) and FeNO (P = 0.03). A consistent pattern of association for lung function variables was observed when stratifying by atopy. There was a negative association of BMI z-score with FeNO in atopic subjects (P = 0.006), but not in non-atopic subjects (P = 0.46).
Excess weight disproportionately impacts lung volumes and airflow in children from the general population, independent of atopic status. Excess weight inversely affects FeNO in atopic but not in non-atopic children.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0174691</identifier><identifier>PMID: 28376119</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Air flow ; Analysis ; Asthma ; Atopy ; Bioinformatics ; Biology and Life Sciences ; Body mass ; Body Mass Index ; Body size ; Body weight ; Child ; Child, Preschool ; Children ; Exhalation - physiology ; Female ; Forced Expiratory Volume ; Health aspects ; Health sciences ; Hospitals ; Humans ; Hypersensitivity, Immediate - complications ; Hypersensitivity, Immediate - physiopathology ; Immunology ; Lung - physiopathology ; Lungs ; Male ; Maximal Midexpiratory Flow Rate ; Medical research ; Medicine ; Medicine and Health Sciences ; Mortality ; Nitric oxide ; Nitric Oxide - physiology ; Obesity ; Obesity - complications ; Obesity - pathology ; Obesity - physiopathology ; Overweight ; Parameter modification ; Peak Expiratory Flow Rate ; Pediatrics ; People and Places ; Physicians ; Population ; Pulmonary Ventilation ; Respiratory diseases ; Respiratory function ; Respiratory Function Tests ; Rheumatology ; Vital Capacity</subject><ispartof>PloS one, 2017-04, Vol.12 (4), p.e0174691-e0174691</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Yao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Yao et al 2017 Yao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4c5593428f6af0eefa56e1f1fda5ca3538e3a7ebcebbb1ce30d5fb58191d05be3</citedby><cites>FETCH-LOGICAL-c692t-4c5593428f6af0eefa56e1f1fda5ca3538e3a7ebcebbb1ce30d5fb58191d05be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1884098678/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1884098678?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28376119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Yang-Ching</contributor><creatorcontrib>Yao, Tsung-Chieh</creatorcontrib><creatorcontrib>Tsai, Hui-Ju</creatorcontrib><creatorcontrib>Chang, Su-Wei</creatorcontrib><creatorcontrib>Chung, Ren-Hua</creatorcontrib><creatorcontrib>Hsu, Jing-Ya</creatorcontrib><creatorcontrib>Tsai, Ming-Han</creatorcontrib><creatorcontrib>Liao, Sui-Ling</creatorcontrib><creatorcontrib>Hua, Man-Chin</creatorcontrib><creatorcontrib>Lai, Shen-Hao</creatorcontrib><creatorcontrib>Chen, Li-Chen</creatorcontrib><creatorcontrib>Yeh, Kuo-Wei</creatorcontrib><creatorcontrib>Tseng, Yu-Lun</creatorcontrib><creatorcontrib>Lin, Wan-Chen</creatorcontrib><creatorcontrib>Chang, Su-Ching</creatorcontrib><creatorcontrib>Huang, Jing-Long</creatorcontrib><creatorcontrib>Prediction of Allergies in Taiwanese Children (PATCH) Study Group</creatorcontrib><creatorcontrib>on behalf of the Prediction of Allergies in Taiwanese Children (PATCH) Study Group</creatorcontrib><title>Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy.
We investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy.
There were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P<0.001), after controlling for confounders. The beta coefficient for FEV1 (0.084) was smaller than that for FVC (0.111). In contrast, a negative association was found between BMI z-score and FEV1/FVC ratio (P<0.001) and FeNO (P = 0.03). A consistent pattern of association for lung function variables was observed when stratifying by atopy. There was a negative association of BMI z-score with FeNO in atopic subjects (P = 0.006), but not in non-atopic subjects (P = 0.46).
Excess weight disproportionately impacts lung volumes and airflow in children from the general population, independent of atopic status. Excess weight inversely affects FeNO in atopic but not in non-atopic children.</description><subject>Adolescent</subject><subject>Air flow</subject><subject>Analysis</subject><subject>Asthma</subject><subject>Atopy</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Exhalation - physiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Health aspects</subject><subject>Health sciences</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - complications</subject><subject>Hypersensitivity, Immediate - physiopathology</subject><subject>Immunology</subject><subject>Lung - physiopathology</subject><subject>Lungs</subject><subject>Male</subject><subject>Maximal Midexpiratory Flow Rate</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mortality</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - physiology</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - pathology</subject><subject>Obesity - physiopathology</subject><subject>Overweight</subject><subject>Parameter modification</subject><subject>Peak Expiratory Flow Rate</subject><subject>Pediatrics</subject><subject>People and Places</subject><subject>Physicians</subject><subject>Population</subject><subject>Pulmonary Ventilation</subject><subject>Respiratory diseases</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Rheumatology</subject><subject>Vital Capacity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEUxwdRbK1-A9EBQRTcNZnMJXkRSvGyUFjw9iYhk5zsZskm02Smbr-9WXdadqQPkoeE5Hf-Odcse47RHJMGv9_4IThh5513MEe4KWuGH2SnmJFiVheIPDw6n2RPYtwgVBFa14-zk4KSpsaYnWa_li1E09_kysQu-M6H3ngnerA3udl2QvYxt4Nb5dfeDluI73Jhgrb-dy6cymG3FhZU7kwfjMz9zijIjcvl2lgVwD3NHmlhIzwb97Psx6eP3y--zC6XnxcX55czWbOin5WyqhgpC6proRGAFlUNWGOtRCUFSV4DEQ20Etq2xRIIUpVuK4oZVqhqgZxlLw-6nfWRj5mJHFNaIkbrhiZicSCUFxveBbMV4YZ7YfjfCx9WXKTQpQWumzJpMsV0W5YYgKG6UHVJBaUVogQnrQ_jb0O7BSXB9UHYiej0xZk1X_lrngJBhDRJ4M0oEPzVALHnWxMlWCsc-OHgd5nqhvboq3_Q-6MbqVUqBzdO-_Sv3Ivy8zK5jRljZaLm91BpKdgamdpIm3Q_MXg7MUhMD7t-JYYY-eLb1_9nlz-n7Osjdg3C9uuY-mvfenEKlgdQBh9jAH2XZIz4fgpus8H3U8DHKUhmL44LdGd02_bkDzp_BFU</recordid><startdate>20170404</startdate><enddate>20170404</enddate><creator>Yao, Tsung-Chieh</creator><creator>Tsai, Hui-Ju</creator><creator>Chang, Su-Wei</creator><creator>Chung, Ren-Hua</creator><creator>Hsu, Jing-Ya</creator><creator>Tsai, Ming-Han</creator><creator>Liao, Sui-Ling</creator><creator>Hua, Man-Chin</creator><creator>Lai, Shen-Hao</creator><creator>Chen, Li-Chen</creator><creator>Yeh, Kuo-Wei</creator><creator>Tseng, Yu-Lun</creator><creator>Lin, Wan-Chen</creator><creator>Chang, Su-Ching</creator><creator>Huang, Jing-Long</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170404</creationdate><title>Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children</title><author>Yao, Tsung-Chieh ; Tsai, Hui-Ju ; Chang, Su-Wei ; Chung, Ren-Hua ; Hsu, Jing-Ya ; Tsai, Ming-Han ; Liao, Sui-Ling ; Hua, Man-Chin ; Lai, Shen-Hao ; Chen, Li-Chen ; Yeh, Kuo-Wei ; Tseng, Yu-Lun ; Lin, Wan-Chen ; Chang, Su-Ching ; Huang, Jing-Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4c5593428f6af0eefa56e1f1fda5ca3538e3a7ebcebbb1ce30d5fb58191d05be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Air flow</topic><topic>Analysis</topic><topic>Asthma</topic><topic>Atopy</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Exhalation - physiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - complications</topic><topic>Hypersensitivity, Immediate - physiopathology</topic><topic>Immunology</topic><topic>Lung - physiopathology</topic><topic>Lungs</topic><topic>Male</topic><topic>Maximal Midexpiratory Flow Rate</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Mortality</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - physiology</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - pathology</topic><topic>Obesity - physiopathology</topic><topic>Overweight</topic><topic>Parameter modification</topic><topic>Peak Expiratory Flow Rate</topic><topic>Pediatrics</topic><topic>People and Places</topic><topic>Physicians</topic><topic>Population</topic><topic>Pulmonary Ventilation</topic><topic>Respiratory diseases</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Rheumatology</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yao, Tsung-Chieh</creatorcontrib><creatorcontrib>Tsai, Hui-Ju</creatorcontrib><creatorcontrib>Chang, Su-Wei</creatorcontrib><creatorcontrib>Chung, Ren-Hua</creatorcontrib><creatorcontrib>Hsu, Jing-Ya</creatorcontrib><creatorcontrib>Tsai, Ming-Han</creatorcontrib><creatorcontrib>Liao, Sui-Ling</creatorcontrib><creatorcontrib>Hua, Man-Chin</creatorcontrib><creatorcontrib>Lai, Shen-Hao</creatorcontrib><creatorcontrib>Chen, Li-Chen</creatorcontrib><creatorcontrib>Yeh, Kuo-Wei</creatorcontrib><creatorcontrib>Tseng, Yu-Lun</creatorcontrib><creatorcontrib>Lin, Wan-Chen</creatorcontrib><creatorcontrib>Chang, Su-Ching</creatorcontrib><creatorcontrib>Huang, Jing-Long</creatorcontrib><creatorcontrib>Prediction of Allergies in Taiwanese Children (PATCH) Study Group</creatorcontrib><creatorcontrib>on behalf of the Prediction of Allergies in Taiwanese Children (PATCH) Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yao, Tsung-Chieh</au><au>Tsai, Hui-Ju</au><au>Chang, Su-Wei</au><au>Chung, Ren-Hua</au><au>Hsu, Jing-Ya</au><au>Tsai, Ming-Han</au><au>Liao, Sui-Ling</au><au>Hua, Man-Chin</au><au>Lai, Shen-Hao</au><au>Chen, Li-Chen</au><au>Yeh, Kuo-Wei</au><au>Tseng, Yu-Lun</au><au>Lin, Wan-Chen</au><au>Chang, Su-Ching</au><au>Huang, Jing-Long</au><au>Chen, Yang-Ching</au><aucorp>Prediction of Allergies in Taiwanese Children (PATCH) Study Group</aucorp><aucorp>on behalf of the Prediction of Allergies in Taiwanese Children (PATCH) Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-04-04</date><risdate>2017</risdate><volume>12</volume><issue>4</issue><spage>e0174691</spage><epage>e0174691</epage><pages>e0174691-e0174691</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The current literature focusing on the effect of obesity and overweight on lung function and fraction of exhaled nitric oxide (FeNO) in children, particularly among healthy children of non-European descent, remains controversial. Furthermore, whether the relationship of obesity and overweight with lung function and FeNO in children is modified by atopy is unclear. The objective of this study was to examine the effect of excess weight on lung function parameters and FeNO among Asian children, with a particular focus on exploring the potential effect modification by atopy.
We investigated the effect of excess weight on lung function and FeNO in a population sample of 1,717 children aged 5 to 18 years and explored the potential modifying effect of atopy.
There were positive associations of body mass index (BMI) z-score with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), and forced expiratory flow at 25-75% (FEF25-75) (all P<0.001), after controlling for confounders. The beta coefficient for FEV1 (0.084) was smaller than that for FVC (0.111). In contrast, a negative association was found between BMI z-score and FEV1/FVC ratio (P<0.001) and FeNO (P = 0.03). A consistent pattern of association for lung function variables was observed when stratifying by atopy. There was a negative association of BMI z-score with FeNO in atopic subjects (P = 0.006), but not in non-atopic subjects (P = 0.46).
Excess weight disproportionately impacts lung volumes and airflow in children from the general population, independent of atopic status. Excess weight inversely affects FeNO in atopic but not in non-atopic children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28376119</pmid><doi>10.1371/journal.pone.0174691</doi><tpages>e0174691</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-04, Vol.12 (4), p.e0174691-e0174691 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1884098678 |
| source | Access via ProQuest (Open Access); PubMed Central |
| subjects | Adolescent Air flow Analysis Asthma Atopy Bioinformatics Biology and Life Sciences Body mass Body Mass Index Body size Body weight Child Child, Preschool Children Exhalation - physiology Female Forced Expiratory Volume Health aspects Health sciences Hospitals Humans Hypersensitivity, Immediate - complications Hypersensitivity, Immediate - physiopathology Immunology Lung - physiopathology Lungs Male Maximal Midexpiratory Flow Rate Medical research Medicine Medicine and Health Sciences Mortality Nitric oxide Nitric Oxide - physiology Obesity Obesity - complications Obesity - pathology Obesity - physiopathology Overweight Parameter modification Peak Expiratory Flow Rate Pediatrics People and Places Physicians Population Pulmonary Ventilation Respiratory diseases Respiratory function Respiratory Function Tests Rheumatology Vital Capacity |
| title | Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T18%3A04%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obesity%20disproportionately%20impacts%20lung%20volumes,%20airflow%20and%20exhaled%20nitric%20oxide%20in%20children&rft.jtitle=PloS%20one&rft.au=Yao,%20Tsung-Chieh&rft.aucorp=Prediction%20of%20Allergies%20in%20Taiwanese%20Children%20(PATCH)%20Study%20Group&rft.date=2017-04-04&rft.volume=12&rft.issue=4&rft.spage=e0174691&rft.epage=e0174691&rft.pages=e0174691-e0174691&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0174691&rft_dat=%3Cgale_plos_%3EA488519994%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-4c5593428f6af0eefa56e1f1fda5ca3538e3a7ebcebbb1ce30d5fb58191d05be3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1884098678&rft_id=info:pmid/28376119&rft_galeid=A488519994&rfr_iscdi=true |