Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study

Cannabis use is associated with reduced prevalence of obesity and diabetes mellitus (DM) in humans and mouse disease models. Obesity and DM are a well-established independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most prevalent liver disease globally. The effects of cannabis...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0176416-e0176416
Main Authors: Adejumo, Adeyinka Charles, Alliu, Samson, Ajayi, Tokunbo Opeyemi, Adejumo, Kelechi Lauretta, Adegbala, Oluwole Muyiwa, Onyeakusi, Nnaemeka Egbuna, Akinjero, Akintunde Micheal, Durojaiye, Modupeoluwa, Bukong, Terence Ndonyi
Format: Article
Language:English
Subjects:
Acceleration
Adipose tissue
Adolescents
Adult
Adults
Age
Aging (artificial)
Aging (natural)
Alcohol use
Analysis
Arteriosclerosis
Atherosclerosis
Biology and Life Sciences
Biomedical engineering
Biomedical materials
Biotechnology
Black people
Body weight loss
Cannabinoids
Cannabis
Cardiovascular diseases
Case-Control Studies
Codes
Computer programs
Cross-Sectional Studies
Databases, Factual
Diabetes
Diagnosis
Digestive tract
Diseases
Drug abuse
Drug dosages
Epidemiology
Exercise
Exposure
Fatty liver
Female
Gastrointestinal tract
Health aspects
Health care costs
Health risks
Heart
Heart diseases
Hospital costs
Hospitals
Humans
Hyperlipidemia
Income
Insulin resistance
Interleukin 6
Life Sciences
Liver diseases
Lung diseases
Male
Marijuana
Marijuana Smoking
Maternal & child health
Medication
Medicine
Medicine and Health Sciences
Mental disorders
Metabolic disorders
Metabolism
Middle Aged
Non-alcoholic Fatty Liver Disease - epidemiology
Obesity
Patients
Pharmaceutical sciences
Pharmacology
Physical activity
Physical fitness
Phytopathology and phytopharmacy
Population
Population studies
Prevalence
Prevalence studies (Epidemiology)
Protective Factors
Risk factors
Rodents
Santé publique et épidémiologie
Social Sciences
Socioeconomic factors
Studies
Surveys
Tobacco
Transplantation
Vegetal Biology
Vitamin D
Weight control
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Summary:Cannabis use is associated with reduced prevalence of obesity and diabetes mellitus (DM) in humans and mouse disease models. Obesity and DM are a well-established independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most prevalent liver disease globally. The effects of cannabis use on NAFLD prevalence in humans remains ill-defined. Our objective is to determine the relationship between cannabis use and the prevalence of NAFLD in humans. We conducted a population-based case-control study of 5,950,391 patients using the 2014 Healthcare Cost and Utilization Project (HCUP), Nationwide Inpatient Survey (NIS) discharge records of patients 18 years and older. After identifying patients with NAFLD (1% of all patients), we next identified three exposure groups: non-cannabis users (98.04%), non-dependent cannabis users (1.74%), and dependent cannabis users (0.22%). We adjusted for potential demographics and patient related confounders and used multivariate logistic regression (SAS 9.4) to determine the odds of developing NAFLD with respects to cannabis use. Our findings revealed that cannabis users (dependent and non-dependent) showed significantly lower NAFLD prevalence compared to non-users (AOR: 0.82[0.76-0.88]; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176416