A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression

The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Ge...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0176067-e0176067
Main Authors: Navarro, Gemma, Martínez-Pinilla, Eva, Sánchez-Melgar, Alejandro, Ortiz, Raquel, Noé, Véronique, Martín, Mairena, Ciudad, Carlos, Franco, Rafael
Format: Article
Language:English
Subjects:
Adenosine
Analysis
Animals
Antioxidants
Biochemistry
Biology
Biology and Life Sciences
Brain tumors
Care and treatment
Cell Line
Central nervous system
Cerebral cortex
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Computer and Information Sciences
Disease
Down-Regulation - drug effects
Drug development
Drugs
Dynamin
Expressió gènica
Gene expression
Gene Expression - drug effects
Genes
Genetic aspects
Genomics
Glioma
Glioma cells
Gliomas
Health aspects
Medicine and Health Sciences
Mice
Mode of action
Musculoskeletal system
Nanotechnology
Network analysis
Neural networks
Neuroglia - drug effects
Neuroglia - metabolism
Neuronal-glial interactions
Neurons - drug effects
Neurons - metabolism
Neuroprotection
Neuroprotective Agents - pharmacology
Neurotransmitter release
Oxidative stress
Pharmacy
Physiology
Research and Analysis Methods
Resveratrol
Rodents
Sistema nerviós central
Skeletal muscle
Stilbenes - pharmacology
Studies
Synaptobrevin
Tissue inhibitor of metalloproteinase 2
Up-Regulation - drug effects
Vitamin E
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176067