Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes

Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied o...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0176650-e0176650
Main Authors: Dion, François, Dumayne, Christopher, Henley, Nathalie, Beauchemin, Stéphanie, Arias, Edward B, Leblond, François A, Lesage, Sylvie, Lefrançois, Stéphane, Cartee, Gregory D, Pichette, Vincent
Format: Article
Language:English
Subjects:
Accident prevention
Adipose tissue
Age
Anatomy
Anesthesia
Animal models
Animals
Biocompatibility
Biology and Life Sciences
Blood glucose
Brain
Carbohydrate metabolism
Carbohydrates
Cardiovascular diseases
Carriers
Cellular Biology
Complications and side effects
Control
Convergence
Coronary artery disease
Creatinine
Cytotoxicity
Death
Defects
Diabetes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Type 2 - metabolism
Disease Progression
Disease resistance
Endocrinology
Glucose
Glucose - metabolism
Glucose Transporter Type 4 - metabolism
Glycosuria - metabolism
Health risks
Heart
Heart diseases
Homeostasis
Human health and pathology
Information dissemination
Insulin resistance
Insulin Resistance - physiology
Intestine
Kidney diseases
Kidney transplantation
Kidneys
Life Sciences
Liver - metabolism
Male
Medical research
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Metabolism
Modulation
Mortality
Muscle, Skeletal - metabolism
Muscles
Nephrectomy
Organs
Pharmacology
Physical Sciences
Physiological aspects
Physiology
Rats, Sprague-Dawley
Rats, Zucker
Renal failure
Renal Insufficiency, Chronic - metabolism
Risk
Risk factors
Rivers
RNA, Messenger - metabolism
Rodents
Sodium-Glucose Transport Proteins - metabolism
Surgery
Tissue Culture Techniques
Toxicity
Type 2 diabetes
Urine
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Summary:Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied on two different rat strains. First, in a 5/6th nephrectomised Sprague-Dawley rat model of chronic kidney disease, we observed a correlation between the severity of chronic kidney disease and hyperglycemia as evaluated by serum fructosamine levels (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176650