Predictive factors of right paraesophageal lymph node metastasis in papillary thyroid carcinoma: Single center experience and meta-analysis

We performed this retrospective study to identify predictors of right paraesophageal lymph node metastasis, and reviewed previous studies related to this topic. Between June 2005 and March 2015, 1107 patients were diagnosed with papillary thyroid carcinoma and underwent surgery at Pusan National Uni...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0177956-e0177956
Main Authors: Park, Young Min, Lee, Sang Min, Kim, Dong Won, Shin, Sung-Chan, Lee, Byung-Joo
Format: Article
Language:English
Subjects:
Adult
Age
Arteries
Biological markers
Biology and Life Sciences
Biomedical materials
Biopsy
Cancer
Cancer metastasis
Carcinoma - pathology
Carcinoma - surgery
Carcinoma, Papillary
Carotid arteries
Clinical trials
Colleges & universities
Computation
Computed tomography
Confidence intervals
Diagnosis
Dissection
Esophagus
Esophagus - pathology
Esophagus - surgery
Fascia
Female
Head
Head and neck
Humans
Hyoid bone
Hypocalcemia
Incidence
Independent variables
Lesions
Lymph Node Excision - methods
Lymph nodes
Lymphatic Metastasis
Male
Malignancy
Mathematical models
Medical records
Medicine
Medicine and Health Sciences
Meta-analysis
Metastases
Middle Aged
Morbidity
Neck Dissection - methods
Physical Sciences
Predictions
Regression analysis
Research and Analysis Methods
Retrospective Studies
Risk Factors
Searching
Statistical analysis
Statistical tests
Studies
Surgery
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary
Thyroid gland
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy - methods
Tomography
Trachea
Ultrasound
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Description
Summary:We performed this retrospective study to identify predictors of right paraesophageal lymph node metastasis, and reviewed previous studies related to this topic. Between June 2005 and March 2015, 1107 patients were diagnosed with papillary thyroid carcinoma and underwent surgery at Pusan National University Hospital. Right paraesophageal lymph node metastasis was observed in 171 (15.4%) patients. Multivariate analyses showed that the risk of right paraesophageal metastasis was significantly associated with tumor size, location, a higher number of metastatic central lymph nodes, and lateral lymph node metastasis. In a meta-analysis of the eligible studies, tumor size, number of metastatic central lymph nodes, and lateral lymph node metastasis showed significant relationships with the risk of right paraesophageal metastasis. In patients with risk factors such as those identified in our study, the possibility of right paraesophageal metastasis should be kept in mind, and careful inspection and dissection are required.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0177956