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Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity

About the Authors: Michael P. Rout Affiliation: The Rockefeller University, New York, New York, United States of America Samson O. Obado Affiliation: The Rockefeller University, New York, New York, United States of America Sergio Schenkman Affiliation: Universidade Federal de São Paulo, São Paulo, B...

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Published in:PLoS pathogens 2017-03, Vol.13 (3), p.e1006170-e1006170
Main Authors: Rout, Michael P, Obado, Samson O, Schenkman, Sergio, Field, Mark C
Format: Article
Language:English
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Summary:About the Authors: Michael P. Rout Affiliation: The Rockefeller University, New York, New York, United States of America Samson O. Obado Affiliation: The Rockefeller University, New York, New York, United States of America Sergio Schenkman Affiliation: Universidade Federal de São Paulo, São Paulo, Brazil ORCID http://orcid.org/0000-0001-9353-8480 Mark C. Field * E-mail: mfield@mac.com Affiliation: Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom ORCID http://orcid.org/0000-0002-4866-2885Citation: Rout MP, Obado SO, Schenkman S, Field MC (2017) Specialising the parasite nucleus: With annual death rates exceeding a million people and even higher numbers afflicted by disability and compromised agricultural productivity, the organisms causing tropical diseases like leishmaniasis, trypanosomiasis, malaria, and toxoplasmosis represent an ongoing challenge. [...]the nucleus has a double membrane punctured by nuclear pores, nuclear pore complexes (NPCs) that fill these pores, a nucleolus responsible for ribosomal RNA transcription and ribosome assembly, heterochromatin, Cajal bodies, and other nuclear subdomains, together with a filamentous lamina subtending the NE, all of which appear to be highly conserved nuclear features. Relationships are based on recent views of the branching order but should not be considered definitive. https://doi.org/10.1371/journal.ppat.1006170.g001 For example, by negative stain electron microscopy, the NPCs of organisms across the range of eukaryotes are extremely similar, bearing 8-fold symmetry and roughly similar dimensions. Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi. The Trypanosoma brucei AIR9-like protein is cytoskeleton-associated and...
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006170