Assessment of asthma severity in adults with ever asthma: A continuous score

In epidemiological studies, continuous measures of asthma severity should be used to catch the heterogeneity of phenotypes. This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiologic...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0177538-e0177538
Main Authors: Calciano, Lucia, Corsico, Angelo Guido, Pirina, Pietro, Trucco, Giulia, Jarvis, Deborah, Janson, Christer, Accordini, Simone
Format: Article
Language:English
Subjects:
Adult
Adults
Air flow
Air pollution
Analysis
Anti-Asthmatic Agents - pharmacology
Anti-Asthmatic Agents - therapeutic use
Asthma
Asthma - diagnosis
Asthma - drug therapy
Balances (scales)
Biology and Life Sciences
Bronchitis
Bronchoconstriction
Care and treatment
Chest
Children
Chronic illnesses
Chronic obstructive pulmonary disease
Classification
Continuity (mathematics)
Correlation analysis
Data processing
Diagnosis
Diseases
Dosage and administration
Drugs
Epidemiology
Evaluation
Factor analysis
Female
Flow charts
Format
Fruits
Genetics
Health
Health aspects
Heart
Heterogeneity
Humans
Hypersensitivity
Interleukin 13
Lung diseases
Male
Medical services
Medical statistics
Medicine and Health Sciences
Methacholine
Morbidity
Night
Outdoor air quality
Patient outcomes
Peat
Phenotyping
Physical Sciences
Pollution
Polymorphism
Population
Population studies
Public health
Research and Analysis Methods
Respiration
Respiratory diseases
Respiratory function
Respiratory system agents
Rhinitis
Risk assessment
Risk factors
Severity of Illness Index
Statistical analysis
Studies
Thorax
Tightness
Values
Variables
Young adults
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Summary:In epidemiological studies, continuous measures of asthma severity should be used to catch the heterogeneity of phenotypes. This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiological studies. Respiratory symptoms, anti-asthmatic treatment and lung function were measured on 520 patients with ever asthma aged 20-64 years from the general Italian population (GEIRD study; 2007/2010). The variables that represent the same dimension of asthma severity were identified through an exploratory factor analysis and were summarized through a multiple factor analysis. Only respiratory symptoms and anti-asthmatic treatment were summarized in a continuous score (STS). STS ranges from 0 (no symptoms/treatment) to 10 (maximum symptom frequency and treatment intensity). STS was positively correlated with the Global Initiative for Asthma classification of asthma severity computed on the 137 cases with a doctor's diagnosis (Spearman's coefficient = 0.61, p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0177538