Assessment of asthma severity in adults with ever asthma: A continuous score

In epidemiological studies, continuous measures of asthma severity should be used to catch the heterogeneity of phenotypes. This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiologic...

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Published in:PloS one 2017-05, Vol.12 (5), p.e0177538-e0177538
Main Authors: Calciano, Lucia, Corsico, Angelo Guido, Pirina, Pietro, Trucco, Giulia, Jarvis, Deborah, Janson, Christer, Accordini, Simone
Format: Article
Language:English
Subjects:
Adult
Adults
Air flow
Air pollution
Analysis
Anti-Asthmatic Agents - pharmacology
Anti-Asthmatic Agents - therapeutic use
Asthma
Asthma - diagnosis
Asthma - drug therapy
Balances (scales)
Biology and Life Sciences
Bronchitis
Bronchoconstriction
Care and treatment
Chest
Children
Chronic illnesses
Chronic obstructive pulmonary disease
Classification
Continuity (mathematics)
Correlation analysis
Data processing
Diagnosis
Diseases
Dosage and administration
Drugs
Epidemiology
Evaluation
Factor analysis
Female
Flow charts
Format
Fruits
Genetics
Health
Health aspects
Heart
Heterogeneity
Humans
Hypersensitivity
Interleukin 13
Lung diseases
Male
Medical services
Medical statistics
Medicine and Health Sciences
Methacholine
Morbidity
Night
Outdoor air quality
Patient outcomes
Peat
Phenotyping
Physical Sciences
Pollution
Polymorphism
Population
Population studies
Public health
Research and Analysis Methods
Respiration
Respiratory diseases
Respiratory function
Respiratory system agents
Rhinitis
Risk assessment
Risk factors
Severity of Illness Index
Statistical analysis
Studies
Thorax
Tightness
Values
Variables
Young adults
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creator Calciano, Lucia
Corsico, Angelo Guido
Pirina, Pietro
Trucco, Giulia
Jarvis, Deborah
Janson, Christer
Accordini, Simone
description In epidemiological studies, continuous measures of asthma severity should be used to catch the heterogeneity of phenotypes. This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiological studies. Respiratory symptoms, anti-asthmatic treatment and lung function were measured on 520 patients with ever asthma aged 20-64 years from the general Italian population (GEIRD study; 2007/2010). The variables that represent the same dimension of asthma severity were identified through an exploratory factor analysis and were summarized through a multiple factor analysis. Only respiratory symptoms and anti-asthmatic treatment were summarized in a continuous score (STS). STS ranges from 0 (no symptoms/treatment) to 10 (maximum symptom frequency and treatment intensity). STS was positively correlated with the Global Initiative for Asthma classification of asthma severity computed on the 137 cases with a doctor's diagnosis (Spearman's coefficient = 0.61, p-value
doi_str_mv 10.1371/journal.pone.0177538
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This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiological studies. Respiratory symptoms, anti-asthmatic treatment and lung function were measured on 520 patients with ever asthma aged 20-64 years from the general Italian population (GEIRD study; 2007/2010). The variables that represent the same dimension of asthma severity were identified through an exploratory factor analysis and were summarized through a multiple factor analysis. Only respiratory symptoms and anti-asthmatic treatment were summarized in a continuous score (STS). STS ranges from 0 (no symptoms/treatment) to 10 (maximum symptom frequency and treatment intensity). STS was positively correlated with the Global Initiative for Asthma classification of asthma severity computed on the 137 cases with a doctor's diagnosis (Spearman's coefficient = 0.61, p-value&lt;0.0001) (concurrent validity). Furthermore, using a cohort of 1,097 European asthmatics (ECRHS II study; 1999/2002), increasing STS levels at baseline (1991/1993) were positively associated with long-term outcomes (hospitalization and lost workdays for breathing problems, asthma attack frequency and use of asthma controllers) (predictive validity). Finally, the STS scores computed from the GEIRD and ECRHS II data were comparable (Lin's coefficient = 0.95, p-value&lt;0.0001) (replication analysis). 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heterogeneity of phenotypes. This study aimed at developing and validating continuous measures of asthma severity in adult patients with ever asthma from the general population, to be used in epidemiological studies. Respiratory symptoms, anti-asthmatic treatment and lung function were measured on 520 patients with ever asthma aged 20-64 years from the general Italian population (GEIRD study; 2007/2010). The variables that represent the same dimension of asthma severity were identified through an exploratory factor analysis and were summarized through a multiple factor analysis. Only respiratory symptoms and anti-asthmatic treatment were summarized in a continuous score (STS). STS ranges from 0 (no symptoms/treatment) to 10 (maximum symptom frequency and treatment intensity). STS was positively correlated with the Global Initiative for Asthma classification of asthma severity computed on the 137 cases with a doctor's diagnosis (Spearman's coefficient = 0.61, p-value&lt;0.0001) (concurrent validity). Furthermore, using a cohort of 1,097 European asthmatics (ECRHS II study; 1999/2002), increasing STS levels at baseline (1991/1993) were positively associated with long-term outcomes (hospitalization and lost workdays for breathing problems, asthma attack frequency and use of asthma controllers) (predictive validity). Finally, the STS scores computed from the GEIRD and ECRHS II data were comparable (Lin's coefficient = 0.95, p-value&lt;0.0001) (replication analysis). STS is a valid and replicable measure of asthma severity in adults, which could be used in association studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28542217</pmid><doi>10.1371/journal.pone.0177538</doi><tpages>e0177538</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Adults
Air flow
Air pollution
Analysis
Anti-Asthmatic Agents - pharmacology
Anti-Asthmatic Agents - therapeutic use
Asthma
Asthma - diagnosis
Asthma - drug therapy
Balances (scales)
Biology and Life Sciences
Bronchitis
Bronchoconstriction
Care and treatment
Chest
Children
Chronic illnesses
Chronic obstructive pulmonary disease
Classification
Continuity (mathematics)
Correlation analysis
Data processing
Diagnosis
Diseases
Dosage and administration
Drugs
Epidemiology
Evaluation
Factor analysis
Female
Flow charts
Format
Fruits
Genetics
Health
Health aspects
Heart
Heterogeneity
Humans
Hypersensitivity
Interleukin 13
Lung diseases
Male
Medical services
Medical statistics
Medicine and Health Sciences
Methacholine
Morbidity
Night
Outdoor air quality
Patient outcomes
Peat
Phenotyping
Physical Sciences
Pollution
Polymorphism
Population
Population studies
Public health
Research and Analysis Methods
Respiration
Respiratory diseases
Respiratory function
Respiratory system agents
Rhinitis
Risk assessment
Risk factors
Severity of Illness Index
Statistical analysis
Studies
Thorax
Tightness
Values
Variables
Young adults
title Assessment of asthma severity in adults with ever asthma: A continuous score
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