DEK protein level is a biomarker of CD138positive normal and malignant plasma cells

Overexpression of DEK oncogene is associated with increased proliferation of carcinoma cells and it is observed in several solid tumors due to the amplification of the 6p22.3 chromosomal region where DEK locates. Although the same chromosomal amplification occurs in multiple myeloma (MM), a plasma c...

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Bibliographic Details
Published in:PloS one 2017-05, Vol.12 (5), p.e0178025
Main Authors: Çalışkaner, Zihni Onur, Çakar, Türkan, Özçelik, Emrah, Özdilek, Ahmet, Kim, Annette S, Doğan, Öner, Bosompem, Amma, Grosveld, Gerard, Saka, Bülent, Kandilci, Ayten
Format: Article
Language:English
Subjects:
Aberration
Acute myeloid leukemia
Amplification
Animal models
Antibodies
B-cell lymphoma
Biology
Biology and Life Sciences
Biomarkers - metabolism
Biotechnology
Blood
Bone marrow
Bones
Bortezomib
Breast cancer
Burkitt's lymphoma
Cancer
Cell cycle
Cell death
Cell Line
Cell Line, Tumor
Cell Proliferation
Chemotherapy
Children
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Colorectal carcinoma
Crosslinking
Deoxyribonucleic acid
Diagnosis
Differentiation
Disease detection
DNA
DNA repair
Fluorescence
Gene expression
Genetics
Humans
Immunology
Inhibition
Leukemia
Lymphocytes B
Lymphoma
Malignancy
Mathematical analysis
Mathematical models
Medical prognosis
Medical research
Medicine
Medicine and Health Sciences
Melanoma
Microbiology
Molecular biology
Multiple myeloma
Multiple Myeloma - metabolism
Multiple Myeloma - pathology
Myeloid leukemia
Neoplasia
Oncogene Proteins - genetics
Oncogene Proteins - metabolism
Pathology
Patients
Plasma Cells - metabolism
Plasmas (physics)
Poly-ADP-Ribose Binding Proteins
Probes
Proteins
Research and Analysis Methods
Ribonucleic acid
RNA
RNA, Messenger - genetics
Senescence
Syndecan-1 - metabolism
Tumor cells
Tumors
Urinary bladder
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Summary:Overexpression of DEK oncogene is associated with increased proliferation of carcinoma cells and it is observed in several solid tumors due to the amplification of the 6p22.3 chromosomal region where DEK locates. Although the same chromosomal amplification occurs in multiple myeloma (MM), a plasma cell neoplasm, whether the expression and the copy number of the DEK gene are affected in MM remains elusive. We show that despite the increased copy number in CD138positive MM cells (4 out of 41 MM samples), DEK mRNA expression was down-regulated compared with that in CD138negative bone marrow (BM) cells of the same patients (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0178025