Does published research on non-communicable disease (NCD) in Arab countries reflect NCD disease burden?

• Published in: PloS one 2017-06, Vol.12 (6), p.e0178401-e0178401
• Main Authors: Sibai, Abla M, Singh, Neil V, Jabbour, Samer, Saleh, Shadi, Abdulrahim, Sawsan, Naja, Farah, Yazbek, Soha
• Format: Article
• Language: English
• Subjects: Analysis; Author productivity; Bibliometrics; Biomedical Research; Cancer; Care and treatment; Chronic diseases; Chronic obstructive pulmonary disease; Coefficients; Collaboration; Demographic aspects; Design analysis; Design engineering; Discordance; Documents; Economic analysis; Economic development; Funding; Gap analysis; Global Health; Humans; Income; Institutions; Literature reviews; Medicine and Health Sciences; Middle East; Mortality; Nutrition; Observational studies; People and Places; Populations; Public health; Regression analysis; Research and Analysis Methods; Research methodology; Reviews; Studies; United States; Widening
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0178401

To review trends in non-communicable (NCD) research output in the Arab region, in terms of quantity and quality, study design, setting and focus. We also examined differences by time and place, and assessed gaps between research output and NCD burden. A scoping review of a total of 3,776 NCD-related reports published between 2000 and 2013 was conducted for seven Arab countries. Countries were selected to represent diverse socio-economic development levels in the region: Regression analyses were used to assess trends in publications over time and by country. Research gaps were assessed by examining the degree of match between proportionate literature coverage of the four main NCDs (CVD, cancer, DM, and COPD) and cause-specific proportional mortality rates (PMR). The annual number of NCD publications rose nearly 5-fold during the study period, with higher income countries having the higher publication rates (per million populations) and the most rapid increases. The increase in the publication rate was particularly prominent for descriptive observational studies, while interventional studies and systematic reviews remained infrequent (slope coefficients = 13.484 and 0.883, respectively). Gap analysis showed a mismatch between cause-specific PMR burden and NCD research output, with a relative surplus of reports on cancer (pooled estimate +38.3%) and a relative deficit of reports on CVDs (pooled estimate -30.3%). The widening disparity between higher and lower-income countries and the discordance between research output and disease burden call for the need for ongoing collaboration among Arab academic institutions, funding agencies and researchers to guide country-specific and regional research agendas, support and conduct.