Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture

Cruciate ligament rupture (CR) and associated osteoarthritis (OA) is a common condition in dogs. Dogs frequently develop a second contralateral CR. This study tested the hypothesis that the degree of stifle synovitis and cranial cruciate ligament (CrCL) matrix damage in dogs with CR is correlated wi...

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Bibliographic Details
Published in:PloS one 2017-06, Vol.12 (6), p.e0178086-e0178086
Main Authors: Sample, Susannah J, Racette, Molly A, Hans, Eric C, Volstad, Nicola J, Holzman, Gerianne, Bleedorn, Jason A, Schaefer, Susan L, Waller, 3rd, Kenneth R, Hao, Zhengling, Block, Walter F, Muir, Peter
Format: Article
Language:English
Subjects:
Acid phosphatase (tartrate-resistant)
Animals
Anterior Cruciate Ligament - diagnostic imaging
Anterior Cruciate Ligament - immunology
Anterior Cruciate Ligament - pathology
Anterior Cruciate Ligament Injuries - complications
Anterior Cruciate Ligament Injuries - immunology
Anterior Cruciate Ligament Injuries - pathology
Anterior Cruciate Ligament Injuries - veterinary
Arthroscopy
Biocompatibility
Biology and Life Sciences
Biomedical materials
Blood
Blood vessels
Brain damage
C-reactive protein
C-Reactive Protein - analysis
CD3 antigen
Coagulation factors
Collagen (type I)
Correlation
Cruciate ligaments
Damage assessment
Diagnosis
Diagnostic systems
Dog Diseases - immunology
Dog Diseases - pathology
Dogs
Evaluation
Female
Grading
Injuries
Knee
Lymphocytes
Lymphocytes T
Macrophages
Magnetic resonance
Magnetic Resonance Imaging
Male
Mathematical models
Medical examination
Medicine and Health Sciences
Osteoarthritis
Radiographs
Radiography
Research and Analysis Methods
Resonance
Rupture
Rupturing
Skin & tissue grafts
Skull
Staining
Stifle - pathology
Synovial fluid
Synovial Fluid - immunology
Synovitis
Synovitis - complications
Synovitis - immunology
Synovitis - pathology
Synovitis - veterinary
Therapy
Vessels
Veterinary colleges
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Summary:Cruciate ligament rupture (CR) and associated osteoarthritis (OA) is a common condition in dogs. Dogs frequently develop a second contralateral CR. This study tested the hypothesis that the degree of stifle synovitis and cranial cruciate ligament (CrCL) matrix damage in dogs with CR is correlated with non-invasive diagnostic tests, including magnetic resonance (MR) imaging. We conducted a prospective cohort study of 29 client-owned dogs with an unstable stifle due to complete CR and stable contralateral stifle with partial CR. We evaluated correlation of stifle synovitis and CrCL fiber damage with diagnostic tests including bilateral stifle radiographs, 3.0 Tesla MR imaging, and bilateral stifle arthroscopy. Histologic grading and immunohistochemical staining for CD3+ T lymphocytes, TRAP+ activated macrophages and Factor VIII+ blood vessels in bilateral stifle synovial biopsies were also performed. Serum and synovial fluid concentrations of C-reactive protein (CRP) and carboxy-terminal telopeptide of type I collagen (ICTP), and synovial total nucleated cell count were determined. Synovitis was increased in complete CR stifles relative to partial CR stifles (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0178086