Interval to vascularization development in cirrhotic precursor nodules in patients with hepatitis B and C virus co-infections

With the widespread use of gadoxetic acid-enhanced magnetic resonance imaging, liver nodules appearing as hypovascular in the arterial phase and hypointense in the hepatobiliary phase, defined as hypovascular hypointense nodules, are increasingly detected in patients with cirrhosis and are considere...

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Bibliographic Details
Published in:PloS one 2017-06, Vol.12 (6), p.e0178841-e0178841
Main Authors: Chiu, Nai-Chi, Su, Chien-Wei, Liu, Chien-An, Huang, Yi-Hsiang, Chiou, Yi-You
Format: Article
Language:English
Subjects:
Acids
Aged
Biology and life sciences
Care and treatment
Cirrhosis
Coinfection - complications
Coinfection - diagnostic imaging
Coinfection - pathology
Comparative analysis
Demography
Development and progression
Diffusion
Female
Gastroenterology
Group dynamics
Hazards
Health aspects
Health hazards
Hepatitis
Hepatitis B
Hepatitis B - complications
Hepatitis B - diagnostic imaging
Hepatitis B - pathology
Hepatitis B virus
Hepatitis C
Hepatitis C - complications
Hepatitis C - diagnostic imaging
Hepatitis C - pathology
Hepatitis C virus
Hepatology
Hospitals
Humans
Immunoassay
Incidence
Infections
Laboratories
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver diseases
Magnetic resonance
Magnetic Resonance Imaging
Male
Mathematical models
Medicine
Medicine and Health Sciences
Middle Aged
Multivariate Analysis
Neovascularization, Pathologic - complications
Neovascularization, Pathologic - diagnostic imaging
Neovascularization, Pathologic - epidemiology
NMR
Nodules
Nuclear magnetic resonance
Patients
Physical Sciences
Precursors
Research and Analysis Methods
Resonance
Risk factors
Sex
Sex ratio
Studies
Time Factors
Vascular diseases
Vascularization
Viruses
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Summary:With the widespread use of gadoxetic acid-enhanced magnetic resonance imaging, liver nodules appearing as hypovascular in the arterial phase and hypointense in the hepatobiliary phase, defined as hypovascular hypointense nodules, are increasingly detected in patients with cirrhosis and are considered precursor nodules. We sought to evaluate the interval to vascularization development in hepatitis C virus/hepatitis B virus co-infected-associated precursor nodules (BC-HHN group) compared with that in hepatitis C virus mono-infected-associated precursor nodules (C-HHN group) in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging. The interval to vascularization development was estimated by the Kaplan-Meier method and compared using the Cox proportional hazards model. The mean intervals to vascularization development in the BC-HHN and C-HHN groups were 272.9±31.1 and 603.8±47.6 days, respectively (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0178841