Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis

Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome...

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Bibliographic Details
Published in:PloS one 2017-06, Vol.12 (6), p.e0179074-e0179074
Main Authors: Taubert, Richard, Hardtke-Wolenski, Matthias, Noyan, Fatih, Lalanne, Claudine, Jonigk, Danny, Schlue, Jerome, Krech, Till, Lichtinghagen, Ralf, Falk, Christine S, Schlaphoff, Verena, Bantel, Heike, Muratori, Luigi, Manns, Michael P, Jaeckel, Elmar
Format: Article
Language:English
Subjects:
Adult
Animals
Area Under Curve
Bacterial infections
Biochemistry
Biology and Life Sciences
Biopsy
Care and treatment
Chronic active hepatitis
Cohort Studies
Cytokines
Damage
Deregulation
Diagnostic systems
Diseases
Dosage and administration
Endocrinology
Ferritin
Ferritins - blood
Gastroenterology
Gene expression
Growth factors
Hepatitis
Hepatitis, Autoimmune - blood
Hepatitis, Autoimmune - complications
Hepatitis, Autoimmune - therapy
Hepatocyte growth factor
Hepatocyte Growth Factor - pharmacology
Hepatology
Hepcidin
Hepcidins - metabolism
Histology
Homeostasis
Humans
Hypergammaglobulinemia
Hypergammaglobulinemia - blood
Hypergammaglobulinemia - complications
Hypotheses
Hypotheses (Scientific method)
Immunoglobulins
Immunosuppression
Immunosuppressive agents
Incidence
Infections
Iron
Laboratories
Liver
Liver diseases
Liver transplantation
Medical prognosis
Medical schools
Medicine and Health Sciences
Metabolism
Mice
Pathology
Patients
Reference Standards
Remission
Remission Induction
ROC Curve
Therapy
Training
Transferrin
Transferrins
Transplantation
Transplants & implants
Treatment Outcome
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Summary:Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome in other chronic liver diseases and after liver transplantation. We assessed the capacity of baseline parameters including the iron status to predict the treatment response upon standard therapy in 109 patients with untreated AIH type 1 (AIH-1) in a retrospective single center study. Thereby, a hyperferritinemia (> 2.09 times upper limit of normal; Odds ratio (OR) = 8.82; 95% confidence interval (CI): 2.25-34.52) and lower immunoglobulins (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0179074