Preheating of urine improves the specificity of urinary cryptococcal antigen testing using the lateral flow assay

• Published in: PLoS neglected tropical diseases 2017-05, Vol.11 (5), p.e0005304-e0005304
• Main Authors: Brito-Santos, Fábio, Ferreira, Marcela de Faria, Trilles, Luciana, Muniz, Mauro de Medeiros, Veloso Dos Santos, Valdiléa Gonçalves, Carvalho-Costa, Filipe Anibal, Meyer, Wieland, Wanke, Bodo, Lazéra, Márcia Dos Santos
• Format: Article
• Language: English
• Subjects: AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - urine; Analysis; Antigens; Antigens, Fungal - immunology; Antigens, Fungal - urine; Assaying; Biology and Life Sciences; Biosecurity; Cryptococcosis; Cryptococcosis - complications; Cryptococcosis - diagnosis; Cryptococcosis - urine; Cryptococcus neoformans - metabolism; Diagnostic tests; From Innovation to Application; Fungal infections; Fungi; Heating; HIV Infections - complications; Hot Temperature; Humans; Infectious diseases; Medical research; Medicine and Health Sciences; Microbiology; Point-of-Care Systems; Research and Analysis Methods; Sensitivity and Specificity; Specificity; Studies; Testing; Tropical diseases; Urinalysis; Urinalysis - methods; Urine; Vector-borne diseases
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0005304

About the Authors: Fábio Brito-Santos Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Marcela de Faria Ferreira Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Luciana Trilles Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Mauro de Medeiros Muniz Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Valdiléa Gonçalves Veloso dos Santos Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Filipe Anibal Carvalho-Costa Affiliation: Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil Wieland Meyer Affiliations National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil, Centre for Infectious Diseases and Microbiology, Sydney Medical School-Westmead Hospital, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead Institute for Medical Research, Sydney, New South Wales, Australia Bodo Wanke Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil Márcia dos Santos Lazéra * E-mail: [e-mail] Affiliation: National Institute of Infectious Diseases Evandro Chagas (INI), FIOCRUZ, Rio de Janeiro, Brazil ORCID http://orcid.org/0000-0002-1620-4118Citation: Brito-Santos F, Ferreira MdF, Trilles L, Muniz MdM, Veloso dos Santos VG, Carvalho-Costa FA, et al. Overview A delay in laboratory diagnosis is related to sequelae and death. [...]early diagnosis is the key to decrease the high lethality rate due to cryptococcosis. A delay in laboratory diagnosis is related to sequelae and death. [...]early diagnosis is the key to decrease the...