Pro-inflammatory immune responses are associated with clinical signs and symptoms of human anaplasmosis

Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in...

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Bibliographic Details
Published in:PloS one 2017-06, Vol.12 (6), p.e0179655-e0179655
Main Authors: Schotthoefer, Anna M, Schrodi, Steven J, Meece, Jennifer K, Fritsche, Thomas R, Shukla, Sanjay K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anaplasmosis
Anaplasmosis - complications
Anaplasmosis - immunology
Anaplasmosis - metabolism
Anaplasmosis - pathology
Biology and Life Sciences
Blood
Case-Control Studies
Chemiluminescence
Child
Child, Preschool
Complications
Cytokines
Cytokines - analysis
Diarrhea
Diarrhea - etiology
Female
Hematopoiesis
Humans
Illnesses
Immune response
Immunoassay
Infections
Infectious diseases
Inflammation
Inflammatory response
Interferon
Interleukin 1
Interleukin 10
Interleukin 12
Interleukin 13
Interleukin 2
Interleukin 5
Interleukin 6
Interleukin 8
Laboratories
Lyme disease
Male
Medical records
Medicine and Health Sciences
Middle Aged
Multiplexing
Pathogens
Patients
Physical Sciences
Physicians
Platelet Count
Research and Analysis Methods
Sepsis
Severity of Illness Index
Signs and symptoms
Studies
Th1 Cells - cytology
Th1 Cells - metabolism
Th2 Cells - cytology
Th2 Cells - metabolism
Thrombocytopenia
Tumor necrosis factor
Vomiting
Vomiting - etiology
Young Adult
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Summary:Human anaplasmosis (HA) is an emerging tick-borne disease that may present as a mild flu-like illness or a life threatening, sepsis-like condition. Although disease severity is hypothesized to relate to immunopathology and immune dysfunction in humans, studies to directly measure immune responses in infected humans have been very limited. We quantified cytokines in 80 confirmed HA patients using a multiplex chemiluminescence immunoassay system and compared similarly measured responses in 1000 control subjects. Pro-inflammatory cytokines were significantly elevated in HA patients (all seven p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0179655