Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups

Iron deficiency is common during infancy and therefore iron supplementation is recommended. Recent reports suggest that iron supplementation in already iron replete infants may adversely affect growth, cognitive development, and morbidity. Normal and growth restricted rat pups were given iron daily...

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Published in:PloS one 2017-06, Vol.12 (6), p.e0179713-e0179713
Main Authors: Alexeev, Erica E, He, Xuan, Slupsky, Carolyn M, Lönnerdal, Bo
Format: Article
Language:English
Subjects:
Abundance
Age
Amino acids
Anaerobes
Analysis
Animal cognition
Animals
Animals, Newborn
Avoidance
Babies
Biology and Life Sciences
Birth
Breastfeeding & lactation
Childbirth & labor
Cognition
Cognitive ability
Cognitive development
Diarrhea
Digestive tract
Dose-Response Relationship, Drug
Ecological monitoring
Ecology
Female
Food science
Gastrointestinal tract
Growth
Health aspects
Hematology
Infants
Inositol
Intestinal microflora
Intestines - microbiology
Iron
Iron deficiency
Iron deficiency anemia
Liver
Medicine and Health Sciences
Metabolism
Metabolomics
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Morbidity
Nutrient deficiency
Nutrition research
People and Places
Physiological aspects
Pregnancy
Rats
Rats, Sprague-Dawley
Research and Analysis Methods
Rodents
Studies
Sucrose
Supplementation
Supplements
Urea
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He, Xuan
Slupsky, Carolyn M
Lönnerdal, Bo
description Iron deficiency is common during infancy and therefore iron supplementation is recommended. Recent reports suggest that iron supplementation in already iron replete infants may adversely affect growth, cognitive development, and morbidity. Normal and growth restricted rat pups were given iron daily (30 or 150 μg/d) from birth to postnatal day (PD) 20, and followed to PD56. At PD20, hematology, tissue iron, and the hepatic metabolome were measured. The plasma metabolome and colonic microbial ecology were assessed at PD20 and PD56. T-maze (PD35) and passive avoidance (PD40) tests were used to evaluate cognitive development. Iron supplementation increased iron status in a dose-dependent manner in both groups, but no significant effect of iron on growth was observed. Passive avoidance was significantly lower only in normal rats given high iron compared with controls. In plasma and liver of normal and growth-restricted rats, excess iron increased 3-hydroxybutyrate and decreased several amino acids, urea and myo-inositol. While a profound difference in gut microbiota of normal and growth-restricted rats was observed, with iron supplementation differences in the abundance of strict anaerobes were observed. Excess iron adversely affects cognitive development, which may be a consequence of altered metabolism and/or shifts in gut microbiota.
doi_str_mv 10.1371/journal.pone.0179713
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1932-6203
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source Publicly Available Content Database; PubMed Central
subjects Abundance
Age
Amino acids
Anaerobes
Analysis
Animal cognition
Animals
Animals, Newborn
Avoidance
Babies
Biology and Life Sciences
Birth
Breastfeeding & lactation
Childbirth & labor
Cognition
Cognitive ability
Cognitive development
Diarrhea
Digestive tract
Dose-Response Relationship, Drug
Ecological monitoring
Ecology
Female
Food science
Gastrointestinal tract
Growth
Health aspects
Hematology
Infants
Inositol
Intestinal microflora
Intestines - microbiology
Iron
Iron deficiency
Iron deficiency anemia
Liver
Medicine and Health Sciences
Metabolism
Metabolomics
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Morbidity
Nutrient deficiency
Nutrition research
People and Places
Physiological aspects
Pregnancy
Rats
Rats, Sprague-Dawley
Research and Analysis Methods
Rodents
Studies
Sucrose
Supplementation
Supplements
Urea
title Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups
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