Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis

Drug-resistant tuberculosis (TB) undermines control efforts and its burden is poorly understood in resource-limited settings. We performed a systematic review and meta-analysis to provide an up-to-date summary of the extent of drug-resistant TB in Nigeria. We searched PubMed, Scopus, Embase, HINARI,...

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Bibliographic Details
Published in:PloS one 2017-07, Vol.12 (7), p.e0180996-e0180996
Main Authors: Onyedum, Cajetan C, Alobu, Isaac, Ukwaja, Kingsley Nnanna
Format: Article
Language:English
Subjects:
Adult
Antitubercular Agents - therapeutic use
Biology and Life Sciences
Care and treatment
Diagnosis
Distribution
Drug resistance
Drugs
Extensively drug-resistant tuberculosis
Heterogeneity
HIV
Human immunodeficiency virus
Humans
Leprosy
Libraries
Medical diagnosis
Medical screening
Medicine and Health Sciences
Meta-analysis
Methods
Multidrug resistance
Nigeria - epidemiology
Patients
People and Places
Physical Sciences
Polls & surveys
Prevalence
Research and Analysis Methods
Risk Factors
Scientific papers
Search methods
Teaching hospitals
Tuberculosis
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - epidemiology
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Summary:Drug-resistant tuberculosis (TB) undermines control efforts and its burden is poorly understood in resource-limited settings. We performed a systematic review and meta-analysis to provide an up-to-date summary of the extent of drug-resistant TB in Nigeria. We searched PubMed, Scopus, Embase, HINARI, AJOL, the Cochrane library, Web of Science, and Google Scholar for reports published before January 31 2017, that included any resistance, mono-resistance or multidrug resistance to anti-TB drugs in Nigeria. Summary estimates were calculated using random effects models. We identified 34 anti-TB drug resistance surveys with 8002 adult TB patients consisting of 2982 new and 5020 previously-treated cases. The prevalence rate of any drug resistance among new TB cases was 32.0% (95% CI 24.0-40.0%; 734/2892) and among previously-treated cases, the rate was 53.0% (95% CI 35.0-71.0%; 1467/5020). Furthermore, multidrug resistance among new and previously-treated cases was 6.0% (95% CI 4.0-8.0%;161/2502)and 32.0% (95%CI 20.0-44.0; 357/949), respectively. There was significant heterogeneity between the studies (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0180996