Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study

To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease. A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2017-07, Vol.12 (7), p.e0175836-e0175836
Main Authors: Wu, Ming-Chi, Xu, Xun, Chen, Shan-Ming, Tyan, Yeu-Sheng, Chiou, Jeng-Yuan, Wang, Yu-Hsun, Lin, Li-Chi, Chen, Chyong-Mei, Wei, James Cheng-Chung
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Arthritis
Biology and Life Sciences
Case-Control Studies
Complications and side effects
Control methods
Diabetes
Disease control
Female
Gender
Health care policy
Health risks
Hospitals
Humans
Immunology
Lupus
Male
Medical diagnosis
Medical imaging
Medicine
Medicine and Health Sciences
Nervous system
Odds Ratio
Parkinson disease
Parkinson Disease - epidemiology
Parkinson's disease
Population
Population studies
Research and Analysis Methods
Rheumatology
Risk
Risk Factors
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - epidemiology
Studies
Taiwan - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63
cites cdi_FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63
container_end_page e0175836
container_issue 7
container_start_page e0175836
container_title PloS one
container_volume 12
creator Wu, Ming-Chi
Xu, Xun
Chen, Shan-Ming
Tyan, Yeu-Sheng
Chiou, Jeng-Yuan
Wang, Yu-Hsun
Lin, Li-Chi
Chen, Chyong-Mei
Wei, James Cheng-Chung
description To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease. A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios. A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p < 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p < 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson's disease, Sjogren's syndrome was found to be significantly associated with the risk of Parkinson's disease with an odds ratio of 1.37 (95% CI 1.15-1.65; p < 0.01). This study preliminarily proposed that Sjogren's syndrome was significant associated with an increased risk of Parkinson's disease.
doi_str_mv 10.1371/journal.pone.0175836
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1919520579</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A498443098</galeid><doaj_id>oai_doaj_org_article_0ee91a204cf84757ad6d782aefbc8455</doaj_id><sourcerecordid>A498443098</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63</originalsourceid><addsrcrecordid>eNqNkttu1DAQhiMEoqXwBggiVeJwsYtPiWMukFYVh5UqFdHCreW1J1svib3YCbBvj8Om1Qb1AuXC8fib356ZP8ueYjTHlOM3G98Hp5r51juYI8yLipb3smMsKJmVBNH7B_9H2aMYNwgVtCrLh9kRqThiVPDj7GrZbpXucl_nlxu_DuBexjzunAm-hdy7_LMK362LfogbG0FFeJsvcqc6690vayDXKTTT3nXBN3nserN7nD2oVRPhybieZF8_vL86-zQ7v_i4PFucz3QpSDczNVJkpUq20isuVphSAkWtAFOiOQeKQJVUMFzgtK0Qq0qtgHBsDDOCm5KeZM_3utvGRzk2JEossCgIKrhIxHJPGK82chtsq8JOemXl34APa6lCZ3UDEgEIrAhiuq4YL7gypeEVUVCvdMWKImm9G2_rVy0YDali1UxEpyfOXsu1_ymLAgmMhse8GgWC_9FD7GRro4amUQ58P7ybcJrmUg3o6T_o3dWN1FqlAqyrfbpXD6JywUTFGEWiStT8Dip9Blqb5ga1TfFJwutJwjBb-N2tVR-jXF5--X_24tuUfXHAXoNquuvom35wUpyCbA_q4GMMUN82GSM5mP-mG3IwvxzNn9KeHQ7oNunG7fQP_zv-ug</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1919520579</pqid></control><display><type>article</type><title>Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Wu, Ming-Chi ; Xu, Xun ; Chen, Shan-Ming ; Tyan, Yeu-Sheng ; Chiou, Jeng-Yuan ; Wang, Yu-Hsun ; Lin, Li-Chi ; Chen, Chyong-Mei ; Wei, James Cheng-Chung</creator><contributor>Zheng, Song Guo</contributor><creatorcontrib>Wu, Ming-Chi ; Xu, Xun ; Chen, Shan-Ming ; Tyan, Yeu-Sheng ; Chiou, Jeng-Yuan ; Wang, Yu-Hsun ; Lin, Li-Chi ; Chen, Chyong-Mei ; Wei, James Cheng-Chung ; Zheng, Song Guo</creatorcontrib><description>To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease. A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios. A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p &lt; 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p &lt; 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson's disease, Sjogren's syndrome was found to be significantly associated with the risk of Parkinson's disease with an odds ratio of 1.37 (95% CI 1.15-1.65; p &lt; 0.01). This study preliminarily proposed that Sjogren's syndrome was significant associated with an increased risk of Parkinson's disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0175836</identifier><identifier>PMID: 28704397</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Aged, 80 and over ; Arthritis ; Biology and Life Sciences ; Case-Control Studies ; Complications and side effects ; Control methods ; Diabetes ; Disease control ; Female ; Gender ; Health care policy ; Health risks ; Hospitals ; Humans ; Immunology ; Lupus ; Male ; Medical diagnosis ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Nervous system ; Odds Ratio ; Parkinson disease ; Parkinson Disease - epidemiology ; Parkinson's disease ; Population ; Population studies ; Research and Analysis Methods ; Rheumatology ; Risk ; Risk Factors ; Sjogren's syndrome ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - epidemiology ; Studies ; Taiwan - epidemiology</subject><ispartof>PloS one, 2017-07, Vol.12 (7), p.e0175836-e0175836</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Wu et al 2017 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63</citedby><cites>FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63</cites><orcidid>0000-0002-1235-0679</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1919520579/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1919520579?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28704397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zheng, Song Guo</contributor><creatorcontrib>Wu, Ming-Chi</creatorcontrib><creatorcontrib>Xu, Xun</creatorcontrib><creatorcontrib>Chen, Shan-Ming</creatorcontrib><creatorcontrib>Tyan, Yeu-Sheng</creatorcontrib><creatorcontrib>Chiou, Jeng-Yuan</creatorcontrib><creatorcontrib>Wang, Yu-Hsun</creatorcontrib><creatorcontrib>Lin, Li-Chi</creatorcontrib><creatorcontrib>Chen, Chyong-Mei</creatorcontrib><creatorcontrib>Wei, James Cheng-Chung</creatorcontrib><title>Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease. A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios. A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p &lt; 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p &lt; 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson's disease, Sjogren's syndrome was found to be significantly associated with the risk of Parkinson's disease with an odds ratio of 1.37 (95% CI 1.15-1.65; p &lt; 0.01). This study preliminarily proposed that Sjogren's syndrome was significant associated with an increased risk of Parkinson's disease.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Control methods</subject><subject>Diabetes</subject><subject>Disease control</subject><subject>Female</subject><subject>Gender</subject><subject>Health care policy</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Lupus</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Nervous system</subject><subject>Odds Ratio</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Population</subject><subject>Population studies</subject><subject>Research and Analysis Methods</subject><subject>Rheumatology</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Sjogren's syndrome</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkttu1DAQhiMEoqXwBggiVeJwsYtPiWMukFYVh5UqFdHCreW1J1svib3YCbBvj8Om1Qb1AuXC8fib356ZP8ueYjTHlOM3G98Hp5r51juYI8yLipb3smMsKJmVBNH7B_9H2aMYNwgVtCrLh9kRqThiVPDj7GrZbpXucl_nlxu_DuBexjzunAm-hdy7_LMK362LfogbG0FFeJsvcqc6690vayDXKTTT3nXBN3nserN7nD2oVRPhybieZF8_vL86-zQ7v_i4PFucz3QpSDczNVJkpUq20isuVphSAkWtAFOiOQeKQJVUMFzgtK0Qq0qtgHBsDDOCm5KeZM_3utvGRzk2JEossCgIKrhIxHJPGK82chtsq8JOemXl34APa6lCZ3UDEgEIrAhiuq4YL7gypeEVUVCvdMWKImm9G2_rVy0YDali1UxEpyfOXsu1_ymLAgmMhse8GgWC_9FD7GRro4amUQ58P7ybcJrmUg3o6T_o3dWN1FqlAqyrfbpXD6JywUTFGEWiStT8Dip9Blqb5ga1TfFJwutJwjBb-N2tVR-jXF5--X_24tuUfXHAXoNquuvom35wUpyCbA_q4GMMUN82GSM5mP-mG3IwvxzNn9KeHQ7oNunG7fQP_zv-ug</recordid><startdate>20170713</startdate><enddate>20170713</enddate><creator>Wu, Ming-Chi</creator><creator>Xu, Xun</creator><creator>Chen, Shan-Ming</creator><creator>Tyan, Yeu-Sheng</creator><creator>Chiou, Jeng-Yuan</creator><creator>Wang, Yu-Hsun</creator><creator>Lin, Li-Chi</creator><creator>Chen, Chyong-Mei</creator><creator>Wei, James Cheng-Chung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1235-0679</orcidid></search><sort><creationdate>20170713</creationdate><title>Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study</title><author>Wu, Ming-Chi ; Xu, Xun ; Chen, Shan-Ming ; Tyan, Yeu-Sheng ; Chiou, Jeng-Yuan ; Wang, Yu-Hsun ; Lin, Li-Chi ; Chen, Chyong-Mei ; Wei, James Cheng-Chung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis</topic><topic>Biology and Life Sciences</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Control methods</topic><topic>Diabetes</topic><topic>Disease control</topic><topic>Female</topic><topic>Gender</topic><topic>Health care policy</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunology</topic><topic>Lupus</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Nervous system</topic><topic>Odds Ratio</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Population</topic><topic>Population studies</topic><topic>Research and Analysis Methods</topic><topic>Rheumatology</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Sjogren's syndrome</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>Studies</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Ming-Chi</creatorcontrib><creatorcontrib>Xu, Xun</creatorcontrib><creatorcontrib>Chen, Shan-Ming</creatorcontrib><creatorcontrib>Tyan, Yeu-Sheng</creatorcontrib><creatorcontrib>Chiou, Jeng-Yuan</creatorcontrib><creatorcontrib>Wang, Yu-Hsun</creatorcontrib><creatorcontrib>Lin, Li-Chi</creatorcontrib><creatorcontrib>Chen, Chyong-Mei</creatorcontrib><creatorcontrib>Wei, James Cheng-Chung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Science in Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Ming-Chi</au><au>Xu, Xun</au><au>Chen, Shan-Ming</au><au>Tyan, Yeu-Sheng</au><au>Chiou, Jeng-Yuan</au><au>Wang, Yu-Hsun</au><au>Lin, Li-Chi</au><au>Chen, Chyong-Mei</au><au>Wei, James Cheng-Chung</au><au>Zheng, Song Guo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-07-13</date><risdate>2017</risdate><volume>12</volume><issue>7</issue><spage>e0175836</spage><epage>e0175836</epage><pages>e0175836-e0175836</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate whether Sjogren's syndrome would have an influence on the development of Parkinson's disease. A population-based case-control study was conducted. Participants consisted of 7716 subjects with newly diagnosed Parkinson's disease and a population of 75129 matched control subjects between 2000 and 2010. We measured the risk of Parkinson's disease in association with Sjogren's syndrome by using adjusted odds ratios. A total of 143 Parkinson's disease subjects (1.9%) and 893 control subjects (1.2%) suffered from Sjogren's syndrome (p &lt; 0.001). The crude odds ratio for Parkinson's disease among subjects with Sjogren's syndrome was 1.56 (95% CI 1.30-1.86; p &lt; 0.01). After adjustment for potential confounders which have been proposed that would increase the risk of development of Parkinson's disease, Sjogren's syndrome was found to be significantly associated with the risk of Parkinson's disease with an odds ratio of 1.37 (95% CI 1.15-1.65; p &lt; 0.01). This study preliminarily proposed that Sjogren's syndrome was significant associated with an increased risk of Parkinson's disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28704397</pmid><doi>10.1371/journal.pone.0175836</doi><tpages>e0175836</tpages><orcidid>https://orcid.org/0000-0002-1235-0679</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2017-07, Vol.12 (7), p.e0175836-e0175836
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1919520579
source Publicly Available Content Database; PubMed Central
subjects Age
Aged
Aged, 80 and over
Arthritis
Biology and Life Sciences
Case-Control Studies
Complications and side effects
Control methods
Diabetes
Disease control
Female
Gender
Health care policy
Health risks
Hospitals
Humans
Immunology
Lupus
Male
Medical diagnosis
Medical imaging
Medicine
Medicine and Health Sciences
Nervous system
Odds Ratio
Parkinson disease
Parkinson Disease - epidemiology
Parkinson's disease
Population
Population studies
Research and Analysis Methods
Rheumatology
Risk
Risk Factors
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - epidemiology
Studies
Taiwan - epidemiology
title Impact of Sjogren's syndrome on Parkinson's disease: A nationwide case-control study
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A47%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Sjogren's%20syndrome%20on%20Parkinson's%20disease:%20A%20nationwide%20case-control%20study&rft.jtitle=PloS%20one&rft.au=Wu,%20Ming-Chi&rft.date=2017-07-13&rft.volume=12&rft.issue=7&rft.spage=e0175836&rft.epage=e0175836&rft.pages=e0175836-e0175836&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0175836&rft_dat=%3Cgale_plos_%3EA498443098%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-df0a2ba64bcb79b1332e5fae132c77e30ea6394151c7780486cae271dd4d97d63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1919520579&rft_id=info:pmid/28704397&rft_galeid=A498443098&rfr_iscdi=true