Acute phase proteins as prospective risk markers for arterial stiffness: The Malmö Diet and Cancer cohort

• Published in: PloS one 2017-07, Vol.12 (7), p.e0181718-e0181718
• Main Authors: Muhammad, Iram Faqir, Borné, Yan, Östling, Gerd, Kennbäck, Cecilia, Gottsäter, Mikael, Persson, Margaretha, Nilsson, Peter M, Engström, Gunnar
• Format: Article
• Language: English
• Subjects: Acute phase proteins; Acute phase substances; Acute-Phase Proteins - analysis; Aged; alpha 1-Antitrypsin - analysis; Arteries - physiopathology; Atherosclerosis; Biology and Life Sciences; Blood pressure; C-reactive protein; C-Reactive Protein - analysis; Cancer; Cardiac and Cardiovascular Systems; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Ceruloplasmin; Ceruloplasmin - analysis; Clinical Medicine; Cohort Studies; Complement C3 - analysis; Complement component C3; Diabetes; Diabetes mellitus; Diet; Family medical history; Female; Femur; Follow-Up Studies; Glucose; Haptoglobin; Haptoglobins - analysis; Health risk assessment; Health risks; Heart attacks; Humans; Hypertension; Inflammation; Kardiologi; Kidney diseases; Klinisk medicin; Linear Models; Male; Markers; Medical and Health Sciences; Medicin och hälsovetenskap; Medicine and Health Sciences; Middle Aged; Missing data; Observational studies; Older people; Orosomucoid - analysis; Physical Sciences; Population; Population studies; Prospective Studies; Proteins; Pulse Wave Analysis; Quality; Risk analysis; Risk Factors; Stiffness; Studies; Vascular Stiffness; Velocity; Wave velocity; Women
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0181718

Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave velocity (c-f PWV) in a population-based cohort, and to also explore the effect of low-grade inflammation on the relationship between diabetes and c-f PWV. The study consisted of participants from the Malmö Diet and Cancer study with data from baseline examinations (1991-1994) and follow-up examinations (2007-2012). Arterial stiffness was measured at follow-up by determining c-f PWV. After excluding participants with missing data, the total study population included 2338 subjects. General linear models were used to assess the relationship between baseline acute phase proteins and c-f PWV. After adjusting for traditional risk factors the participants in the 4th quartile vs 1st quartile of alpha-1-antitrypsin (geometric mean: 10.32 m/s vs 10.04 m/s) (p