Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease

• Published in: PloS one 2017-08, Vol.12 (8), p.e0183171-e0183171
• Main Authors: Ikezoe, Kohei, Handa, Tomohiro, Tanizawa, Kiminobu, Chen-Yoshikawa, Toyofumi F, Kubo, Takeshi, Aoyama, Akihiro, Motoyama, Hideki, Hijiya, Kyoko, Tokuda, Shinsaku, Nakatsuka, Yoshinari, Yamamoto, Yuko, Oshima, Ayako, Harashima, Shin-Ichi, Nagai, Sonoko, Hirai, Toyohiro, Date, Hiroshi, Chin, Kazuo
• Format: Article
• Language: English
• Subjects: Adult; Biology and Life Sciences; Biomarkers - analysis; Body mass; Body Mass Index; Cadavers; Carbon monoxide; Care and treatment; Cohort Studies; Computed tomography; Confidence intervals; Development and progression; Diagnosis; Female; Fibrosis; Genetics; Hazards; Health aspects; High resolution; Hospitals; Humans; Idiopathic Pulmonary Fibrosis - diagnosis; Idiopathic Pulmonary Fibrosis - mortality; Idiopathic Pulmonary Fibrosis - pathology; Idiopathic Pulmonary Fibrosis - surgery; Interstitial lung diseases; Intubation; Lung diseases; Lung Diseases, Interstitial - diagnosis; Lung Diseases, Interstitial - mortality; Lung Diseases, Interstitial - pathology; Lung Diseases, Interstitial - surgery; Lung Transplantation; Male; Medical prognosis; Medicine; Medicine and Health Sciences; Middle Aged; Mortality; Nutrition; Patients; Physical Sciences; Pneumonia; Prognosis; Proportional Hazards Models; Pulmonary arteries; Pulmonary fibrosis; Quality of life; Respiratory Function Tests; Surgery; Thoracic surgery; Tomography, X-Ray Computed; Transplantation; Transplants & implants; University graduates; Walking; Xenografts
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0183171

Young patients with advanced interstitial lung disease (ILD) are potential candidates for cadaveric lung transplantation. This study aimed to examine clinical features, outcomes, and prognostic factors in Japanese ILD patients awaiting lung transplantation. We investigated the clinical features and outcomes of 77 consecutive candidates with ILD who were referred to Kyoto University Hospital and subsequently actively listed for lung transplant in the Japan Organ Transplant Network between 2010 and 2014. Of the 77 candidates, 33 had idiopathic pulmonary fibrosis (IPF) and 15 had unclassifiable ILD. During the observational period, 23 patients (30%) received lung transplantations and 49 patients (64%) died before transplantation. Of the 33 patients with IPF, 13 (39%) had a family history of ILD and 13 (39%) had an "inconsistent with usual interstitial pneumonia pattern" on high-resolution computed tomography (HRCT). The median survival time from registration was 16.7 months, and mortality was similar among patients with IPF, unclassifiable ILD, and other ILDs. Using a multivariate stepwise Cox proportional hazards model, 6-min walking distance was shown to be an independent prognostic factor in candidates with ILD (per 10 m, hazard ratio (HR): 0.97; 95% confidence interval (CI): 0.95-0.99, p